Use Social Media in Study of E-Cigarettes

Five-year grant from the National Institutes of Health will support project that is as much about data-gathering methods as it is about public health. Credit: UA

When Facebook announced in September that it would use all that personal data it collects to roll out a new ad platform to rival Google, privacy advocates groaned and marketers grinned.

But what if all that intelligence could be used to crack open one of today’s most pressing — yet least understood — public health issues?

That’s precisely the vision of the University of Arizona’s Daniel Zeng, MIS professor at the Eller College of Management, and Scott Leischow, adjunct faculty in the UA College of Medicine and professor of health services research at Arizona’s Mayo Clinic.

Fusing cutting-edge informatics and public health, their plan to scrape social media to create the world’s best data on e-cigarette usage and marketing recently won a five-year, $2.7 million grant from the National Institutes of Health.

The project will tackle four distinct goals. It will:

Create a massive, real-time and continuously growing data set of what consumers and marketers say about e-cigarettes on sites such as Facebook and Twitter, as well as social media forums focused on e-cigarettes and "vaping."

Mine that content for insights into why people use e-cigarettes, how they believe they affect their health and whether they help them quit smoking.

Document the marketing landscape — all the ways brands and vendors use these channels to promote their products and how consumers respond.

Integrate all of that information in the world’s first one-stop resource for wide-ranging data on e-cigarettes as revealed through social media as a tool for other researchers, health care professionals and more.

While e-cigarettes are relatively new in the U.S. — they were introduced in 2007 — sales are doubling annually and were expected to reach $1 billion last year. Even so, any time public dollars fund research, two questions naturally arise: Why study this? And why study it this way?

"There’s so much we don’t know about e-cigarettes," Leischow says. "The scientific community has found mixed data on whether they’re helpful for smoking cessation. We have questions about how different flavorings impact use, particularly among minors. And many health professionals worry that e-cigarettes may ultimately lead to more young people taking up smoking. All of these blind spots around a product that is still totally unregulated make this a top-priority area for the FDA."

As for why it makes sense to study e-cigarettes in this way, Zeng’s MIS expertise holds the key.  By mining social media in real time, as Zeng and Leischow have proposed, there are a number of strategic advantages:

Data comes from people interacting naturally in their day-to-day lives, thus removing “presentation bias” problems intrinsic in surveys.

The data collection is automated, which means sample size is not constrained by how much money or how many eyeball hours researchers can muster.

The lack of constraint also makes anecdotal information scientifically relevant: One personal story is just that, but 10,000 or 100,000 personal stories over time equal robust statistical data.

Because content is processed by algorithms, not people, data is available in near real time, not months or even years after countless hours of labor-intensive review.

The world of e-cigarettes, like that of any niche product or interest, has its own specialized vocabulary of acronyms and slang, so the research team will first need to construct a base lexical dataset for “training” the computers that will collect and process content.

It’s also one thing to scrape words but a much more complex challenge to automate the process of extracting meaning, so that a computer can spot when someone cites a reason for using e-cigarettes or mentions how the products affect his or her health (both of which first require a computer to detect who is or isn’t a user) or correctly catalog the marketing strategy used in an advertisement.

"We basically will be creating a suite of novel technologies for this study using both established building blocks of informatics and methods that have yet to be developed," Zeng says, "including analysis and visualization tools that were developed here at the U of A. 
Beyond that, we’re relying on proven tools for pattern mining, group behavior prediction, social network analysis and a lot more, but in ways that have never been combined for this level of research and in this topic area."

For Leischow, the knowledge those tools will produce is invaluable.

"There are all kinds of messages out there, from how effective e-cigarettes can be to help smokers quit tobacco to how they’re totally harmless or taste like candy," he says. "It may be that e-cigarettes prove beneficial to public health, or they may be shown to do more harm than good. In either case, it often takes many years for experts to fully recognize how products are being used and how they impact well-being, and even longer for regulation to catch up.

"This time, it’s going to be different. This time, we’re getting out ahead."

Source: UA

The simplest element: Turning hydrogen into 'graphene'

This image is a comparison of the carbon compound graphene with a similar hydrogen-based structure synthesized by Carnegie scientists. Credit: Carneige's Ivan Naumov and Russell Hemley

New work from Carnegie's Ivan Naumov and Russell Hemley delves into the chemistry underlying some surprising recent observations about hydrogen, and reveals remarkable parallels between hydrogen and graphene under extreme pressures. Their work is the cover story in the December issue of Accounts of Chemical Research.

Hydrogen is the most-abundant element in the cosmos. With only a single electron per atom, it is deceptively simple. As a result, hydrogen has been a testing ground for theories of the chemical bond since the birth of quantum mechanics a century ago. Understanding the nature of chemical bonding in extreme environments is crucial for expanding our understanding of matter over the broad range of conditions found in the universe.

Observing hydrogen's behavior under very high pressures has been a great challenge for researchers. But recently teams have been able to observe that at pressures of 2-to-3.5 million times normal atmospheric pressure it transforms into an unexpected structure consisting of layered sheets, rather than a close-packed metal as had been predicted many years ago.

These hydrogen sheets resemble the carbon compound graphene. Graphene's layers are each constructed of a honeycomb structure made of six-atom carbon rings. This conventional carbon graphene, first synthesized about a decade ago, is very light, but incredibly strong, and conducts heat and electricity very efficiently. These properties promise revolutionary technology, including advanced optical electronics for screens, high-functioning photovoltaic cells, and enhanced batteries and other energy storage devices.

The new work from Naumov and Hemley shows that the stability of the unusual hydrogen structure arises from the intrinsic stability of its hydrogen rings. These rings form because of so-called aromaticity, which is well understood in carbon-containing molecules such as benzene, as well as in graphene. Aromatic structures take on a ring-like shape that can be thought of as alternating single and double bonded carbons. But what actually happens is that the electrons that make up these theoretically alternating bonds become delocalized and float in a shared circle around the inside of the ring, increasing stability.

Naumov and Hemley's study also indicates that hydrogen initially becomes a dark poorly conducting metal like graphite instead of a conventional shiny metal and a good conductor, as was originally suggested in theoretical calculations going back to the 1930's using early quantum mechanical models for solids.

Though the discovery of this layered sheet character of dense hydrogen has come as a surprise to many, chemists 30 years ago--before the discovery of graphene--predicted the structure based on simple chemical considerations. Their work is validated and extended by the new findings.

"Overall, our results indicate that chemical bonding occurs over a much broader range of conditions than people had previously considered. However, the structural effects of that chemical bonding under extreme conditions can be very different than that observed under the ordinary conditions that are familiar to us," Hemley said.

Source: Carnegie Institution

‘Smart’ drugs won’t make smart people smarter, research concludes

Dr. Ahmed Dahir Mohamed is in the School of Psychology at The University of Nottingham Malaysia Campus. Credit: The University of Nottingham

The study carried out by Dr Ahmed Dahir Mohamed, in the School of Psychology at The University of Nottingham Malaysia Campus, and published in the open access journal PLOS ONE, showed the drug had negative effects in healthy people.

Dr Mohamed said: "We looked at how the drug acted when you are required to respond accurately and in a timely manner. Our findings were completely opposite to the results we expected."

In a randomised double blind study, 'Modafinil increases the latency of response in the Hayling Sentence Completion Test in Healthy Volunteers: A Randomised Controlled Trial', they administered 32 participants with the drug and 32 with a placebo. All the participants were given a famous neuropsychological task known as the Hayling Sentence Completion Test in which they were asked to respond both quickly and accurately. Dr Mohamed found the drug slowed down reaction times, impaired their ability to respond in a timely manner and failed to improve their performance of the task.

Dr Mohamed said: "It has been argued that Modafinil might improve your performance by delaying your ability to respond. It has been suggested this 'delay dependent improvement' might improve cognitive performance by making people less impulsive. We found no evidence to support those claims.

"Our research showed that when a task required instant reactions the drug just increased reaction times with no improvement to cognitive performance."

This backs up the findings of a previous study carried out by Dr Mohamed and published in September 2014 in The Journal of Creative Behaviour. The study: The Effects of Modafinil on Convergent and Divergent Thinking of Creativity: A Randomised Controlled Trial showed that the so called 'smart' drug impaired the participant's ability to respond in a creative way particularly when they were asked to respond laterally -- outside the box.

Does Modafinil benefit anyone?

When Dr Mohamed looked at participant's ability to problem solve in a creative manner he found that those who weren't particularly creative to start with were improved by the drug while those who were creative were impaired by the drug. He said: "Our study backs up previous research that suggests psychostimulants improve people at the lower end of the spectrum in cognition whereas they impair people who are at the optimum level of cognitive function -- healthy people for example. It looks like Modafinil is not helpful for healthy individuals and it might even impair their ability to respond and might stifle their lateral thinking, while people who have some sort of deficiency in creativity are helped by the drug."

What can make us smarter?

Ahmed Mohamed's research was carried out while he was at Cambridge University. He has since moved to The University of Nottingham Malaysia Campus where he will be looking at the effects of non-pharmacological interventions, such as meditation, exercise and diet on the healthy brain. He is also currently using Electroencephalography (EEG) to study how mindfulness can affect the healthy adolescent brain.

Dr Mohamed said: "What I have found in my doctoral studies is that if you are already a healthy person and functioning at an optimum level, it is really difficult to improve your cognition. But the brain of the adolescent is still in development and you might be able to improve cognition at this stage of our development through positive interaction, healthy diet or mindfulness."

Source: University of Nottingham

Improving taste of alcohol-free beer with aromas from regular beer

Some aromatic substances from alcoholic beer can be extracted and added to alcohol-free varieties.

Consumers often complain that alcohol-free beer is tasteless, but some of the aromas it is lacking can be carried across from regular beer. Researchers from the University of Valladolid (Spain) have developed the technique and a panel of tasters has confirmed its effectiveness.

The alcohol in beer acts as a solvent for a variety of aromatic compounds; therefore, when it is eliminated, as in non-alcoholic beers, the final product loses aromas and some of its taste. It is difficult to recover these compounds, but researchers from the University of Valladolid have done just this using a pervaporation process.

"This technique consists in using a semipermeable membrane to separate two fractions from alcoholic beer: one liquid phase in which alcohol is retained, and another gaseous phase, where the aromatic compounds come in," Carlos A. Blanco, one of the authors explains. "Then, this gaseous phase can be condensed, the aromatic compounds extracted and added to non-alcoholic beer."

To conduct the study, the scientists used a special beer (with 5.5% alcohol) and another reserve beer (6.5%) from which they extracted three aromatic compounds: ethyl acetate, isoamyl acetate and isobutyl alcohol. They then added these substances to two 'almost' alcohol-free beers on the market: low-alcohol beer (less than 1% ABV) and alcohol-free beer (less than 0.1% ABV)..

A panel of experts tasted them. 90% of tasters preferred enriched low-alcohol beer instead of their original factory counterparts, and this percentage rose to 80% for alcohol-free beer. The figures have been published in the 'Journal of Food Engineering'.

"In light of these results, we conclude that the taste is improved, and thus the quality of this 'alcohol-free' beer, as the majority of panellists preferred the beer with aromas to the original," Blanco confirms.

The researchers recognise that this technique cannot yet capture all the aromas and tastes associated with alcoholic beer, but it does show progress in making 'alcohol-free' varieties more palatable for the consumer.

Spain is the primary producer and consumer of alcohol-free beer in the European Union. Around 13% of the beer sold in this country is alcohol-free, consumption of which has increased in recent years due to driving restrictions and for health reasons.

Source: Plataforma SINC

Three new ornamental dogwoods introduced

'Empire', one of the new dogwood varieties, is shown in the photo at 20 years old. 'Empire' features brilliant white bracts and exfoliated bark. Credit: Phillip Wadl

In the nursery and landscape industries, flowering dogwood (Cornus florida), kousa dogwood (Cornus kousa), and their hybrids are the most popular and economically significant members of the genus Cornus. The deciduous trees are highly valued for their spring display of pink, red, or white bracts, brilliant red fall foliage, and exfoliating bark. In the United States alone, retail and wholesale sales of dogwoods account for more than $30 million dollars annually.

In the past, flowering dogwoods were severely affected by dogwood anthracnose and powdery mildew. A program initiated more than 20 years ago at the University of Tennessee resulted in the release of 'Appalachian Spring', the first flowering dogwood cultivar with resistance to dogwood anthracnose, and four powdery mildew resistant cultivars. "We have found that Cornus kousa is more tolerant to anthracnose and powdery mildew than Cornus florida," explained Phillip Wadl, lead author of report published in HortScience. "Hybrids between these two species are generally more vigorous than typical plants of either parent species, and have resistance or tolerance to dogwood anthracnose and powdery mildew."

Wadl and colleagues Mark Windham, Richard Evans, and Robert Trigiano evaluated 400 seedlings of C. kousa for disease resistance and traits such as color, degree of overlap, size of bracts, tree form, and bark and leaf characteristics. The scientists selected three cultivars they named 'Empire', 'Pam's Mountain Bouquet' and 'Red Steeple' for development and eventual release. 'Empire' is a brilliant, white-bracted kousa dogwood that has a columnar form and exfoliating bark. 'Pam's Mountain Bouquet' (patent pending) is a kousa dogwood with a spreading form that features a prolific fused bract display. 'Red Steeple' is a kousa dogwood that features a columnar-shaped canopy with red foliage that fades to green with high temperature and white bracts that have a red tint along the margins.

The authors noted that dogwood anthracnose and powdery mildew were not observed on any of these trees. Analyses showed that 'Empire', 'Pam's Mountain Bouquet', and 'Red Steeple' are genetically distinct from the 26 cultivars and unnamed accessions of Cornus kousa that are maintained in the University of Tennessee's kousa dogwood collection.

The program has applied for a plant patent for 'Pam's Mountain Bouquet'. A limited quantity of budwood has been distributed to wholesale nurseries in Tennessee and Japan, and selected nurseries have been identified to propagate the cultivars.

Source: American Society for Horticultural Science

Moderate consumption of sugary drinks has little impact on adolescents' metabolic health

Sugar-sweetened beverages, such as soft drinks, are the largest source of added sugar in the diets of adolescents in the United States. Credit: Image courtesy of University of Missouri-Columbia

Sugar-sweetened beverages are the largest source of added sugar in the diets of adolescents in the United States, and young adults ages 15-20 consume more of these drinks than any other age group, according to the Centers for Disease Control and Prevention. Adolescent obesity rates, which have quadrupled over the past thirty years, led to widespread scrutiny of added dietary sugars, especially those found in carbonated beverages. Now, MU researchers have found that short-term, moderate consumption of high-fructose and high-glucose beverages has little impact on the metabolic health of weight-stable, physically active adolescents.

"These beverages may not be as unhealthy for adolescents as previously thought, provided that kids stay active," said Jill Kanaley, professor and associate chair in the MU Department of Nutrition and Exercise Physiology. "That physical activity component is really critical in protecting against some of the negative effects of drinking large amounts of sugar-sweetened drinks demonstrated in previous studies."

Kanaley's study measured several aspects of metabolic health, including insulin sensitivity and cholesterol levels, after participants had consumed moderate amounts of either high-glucose or high-fructose beverages every day for two weeks. The high-glucose drink contained 50 grams of glucose and 15 grams of fructose; the high-fructose drink contained 50 grams of fructose and 15 grams of glucose. In comparison, two 12-ounce cans of white soda contain about 50 grams of fructose, although the amount of sugar found in soft drinks varies by brand and type. The researchers used armbands with electronic sensors to monitor physical activity of the participants, all of whom were healthy male and female adolescents ages 15-20.

Although some research has shown that consuming sugary drinks can have detrimental metabolic effects, Kanaley said that the results of these studies have been inconsistent. Previous research often has excluded adolescents and did not measure participants' levels of physical activity. In one of her previous studies, which recently was published in Medicine in Science and Sports, Kanaley found that increased physical activity diminished negative effects associated with high-fructose diets.

"Many parents of adolescents worry about their children's consumption of sweetened beverages," Kanaley said. "I certainly would recommend that they work to reduce their children's intake of sugary drinks, but it also is important for kids to remain active, especially if they are drinking a lot of sugary beverages. In our study, the female adolescents averaged around 8,000 steps per day, and the males averaged about 10,000 steps per day. 

These children weren't athletes, but they had active lifestyles."

Kanaley's article was published in the American Journal of Clinical Nutrition.

Source: University of Missouri-Columbia