Skull sheds light on human-Neanderthal relationship

Retrieved from a cave in northern Israel, the partial skull provides the first evidence that Homo sapiens inhabited that region at the same time as Neanderthals. (Reuters: Nikola Solic)

A partial skull, found in a cave in Israel, is shedding light on the pivotal moment in early human history when our species left Africa and encountered our close cousins the Neanderthals.

Anthropologist Israel Hershkovitz, from Tel Aviv University, called the skull "an important piece of the puzzle of the big story of human evolution."

The findings of the research, led by Hershkovitz, are published today in the journal Nature.

The upper part of the skull - the domed portion without the face or jaws - was unearthed in Manot Cave in Israel's Western Galilee.

Scientific dating techniques determined the skull was about 55,000 years old, a time period when members of our species were thought to have been marching out of Africa,

The researchers say characteristics of the skull suggest the individual was closely related to the first Homo sapiens populations that later colonized Europe.

They also say the skull provides the first evidence that Homo sapiens inhabited that region at the same time as Neanderthals, our closest extinct human relative.

Previous genetic evidence suggests our species and Neanderthals interbred around the time the skull is dated to, with all people of Eurasian ancestry still retaining a small amount of Neanderthal DNA as a result.

"It is the first direct fossil evidence that modern humans and Neanderthals inhabited the same area at the same time," says palaeontologist Bruce Latimer of Case Western Reserve University in Cleveland, another of the researchers.

"The co-existence of these two populations in a confined geographic region at the same time that genetic models predict interbreeding promotes the notion that interbreeding may have occurred in the Levant region," Hershkovitz says.

The robust, large-browed Neanderthals prospered across Europe and Asia from about 350,000 to 40,000 years ago, going extinct sometime after Homo sapiens arrived.

Scientists say our species first appeared about 200,000 years ago in Africa and later migrated outwards. The cave is located along the sole land route for ancient humans to take from Africa into the Middle East, Asia and Europe.

Latimer says he suspects the skull belonged to a woman, although the researchers could not say definitively.

The cave, sealed off for 30,000 years, was discovered in 2008 during sewage line construction work. Hunting tools, perforated seashells perhaps used ornamentally and animal bones have been excavated from the cave, along with further human remains.

Source: ABC

Blazing car murder of 1930 investigated

Slide with Blazing Car victim's sample on it. Sample taken by Sir Bernard Spilsbury.
Credit: University of Leicester

University of Leicester leads collaboration with Northumbria University, Northamptonshire Police and The Royal London Hospital Museum, in investigation of the Blazing Car Murder of 1930

A forensic team from the University of Leicester and Northumbria University has spearheaded an investigation which has shed new light on a murder case from 1930.

A team from the University of Leicester, led by Dr John Bond OBE from the Department of Chemistry and Dr Lisa Smith from the Department of Criminology worked with colleagues from Northumbria University, Northamptonshire Police and The Royal London Hospital Museum to tackle the riddle of the 'Blazing Car Murder' from over 80 years ago.

The case involved the murder of a male in a car fire in Hardingstone, Northamptonshire, on 6 November 1930. Alfred Rouse was convicted, and later hanged, at Bedford Gaol in March 1931, for murdering his victim who to this day, has not been identified.

At the time, a post mortem examination was carried out in the garage of the local public house by the Home Office-appointed pathologist Sir Bernard Spilsbury, working alongside another local pathologist.

Sir Spilsbury reported that lavender coloured material and light brown hair were found at the scene. It was further documented that the victim's jawbone was removed to assist with possible identification and tissue samples taken for microscopical examination.

Two of these tissue samples are still in existence and archived in The Royal London Hospital Museum: one from the prostate to confirm the sex of the victim, and another from the lung to determine whether or not the victim was already dead before the fire was started.

In recent months, attention has turned to the fact that a man named William Briggs left his family home in London to attend a doctor's appointment at around the same time the crime was committed -- and was never seen or heard of again.

As part of their family ancestry research, the relatives of William Briggs wanted to verify earlier generations' belief that their ancestor may have been Rouse's car murder victim.

Last year, a number of William Briggs's relatives approached Northamptonshire Police in an attempt to put the 83-year-old mystery to rest and finally reveal the identity of the victim.

They met with the Force's curator and archivist Richard Cowley, discussed the story of the murder and were shown artefacts relating to the crime which, at the time received worldwide attention.

With the help of Northamptonshire Police, the family contacted University of Leicester academic Dr John Bond OBE. He and Dr Lisa Smith negotiated with The Royal London Hospital museum to allow one of the remaining tissue samples to be examined.

The slide was released with the approval of Professor Richard Trembath, at Queen Mary College University of London. The slide originates from the old Department of Forensic Medicine which formed part of The London Hospital Medical College. The College was merged with Queen Mary College in 1995.

The University of Leicester team considered whether there might just be enough mitochondrial DNA (mtDNA) left on the slide to get a profile to compare with mtDNA from the family.

Mitochondrial DNA is wholly inherited from the maternal line so it is essential to have an unbroken maternal line of descendants to test.

University of Leicester worked with the Northumbria University Centre for Forensic Science and Dr Eleanor Graham, a former member of staff at the University of Leicester, and Victoria Barlow to carry out DNA analysis on the samples to see if there was a match from the sample and the relatives.

Fortunately, the scientists obtained a full single male mtDNA profile from the slide to compare to the family.

Dr John Bond, from the University of Leicester said: "It's been very interesting and rewarding working on such a famous, local murder case. It was quite a unique investigation to be involved in, as the perpetrator had been identified long ago and brought to justice while the victim's identity remained unknown.

"It was a great example of how the scientific and criminological expertise at the University of Leicester and Northumbria University, working together with the police, could provide answers to this family after 83 years."

Detective Chief Superintendent Paul Phillips from Northamptonshire Police said: "From our perspective this is a closed case, the offender Alfred Rouse was convicted of murder and hanged, but this has been a long-standing mystery in Northamptonshire as the identity of the victim has never been established.

"Our work at Northamptonshire Police is victim focused so I was delighted to learn of new opportunities to establish the identity of the victim through the development of forensic science."

Dr Eleanor Graham from Northumbria University stated: "Projects such as this highlight the fact that forensic DNA analysis is not confined to 'catching criminals'. DNA analysis also has a critical role to play in the identification of those who have been killed during criminal acts, accidents or natural disasters, which have occurred recently, or many years ago."

The result is due to be revealed to the family on the BBC's The One Show on a date to be fixed.

Blazing Car Murder background:

Alfred Rouse sustained a head wound in the First World War, which left him with a personality disorder, to the point that he was described as 'a promiscuous rake with an enormous sexual appetite'.

Rouse was a commercial traveller who went all around the country and his promiscuous lifestyle resulted in him facing severe financial problems.

As a consequence, Rouse devised a plan to murder a homeless tramp who would not be missed by anyone which would enable him to stage his own death in a car accident and then disappear to start a new life free from financial restriction.

To that end, Rouse rendered his victim unconscious, placed him in the driver's seat of his car and set the car alight.

Rouse was making his way from the scene but bumped into two local youths keen to see what was going on and take part in some late Bonfire Night celebrations.

This initial contact eventually led to Rouse's arrest. He was convicted at Northampton Assizes and hanged in Bedford on 10 March 1931.

The local Herald newspaper suggested that the identity of Rouse's victim 'would likely remain a mystery forever.' But will it………..?

Source: University of Leicester

Hox cluster found in Crown of Thorns starfish a surprise

A Crown of Thorns starfish, Acanthaster planci, feeding on several species of Montipora corals. The image was taken off the coast of Okinawa near Sesoko Island. Credit: Yuna Zayasu

New research published in the journal genesis, by Kenneth Baughman, Dr. Eiichi Shoguchi, Professor Noriyuki Satoh of the Marine Genomics Unit at the Okinawa Institute of Science and Technology Graduate University, and collaborators from Australia, reports an intact Hox cluster in the Crown of Thorns starfish, Acanthaster planci. This surprising result contrasts with the relatively disorganized Hox cluster found in sea urchins, which are also echinoderms, classification of animals including starfish, sea lilies, and sea cucumbers. Stanford University Professor Christopher Lowe, who studies developmental biology in echinoderms, summarizes the paper: "The translocation of the Hox cluster in echinoderms has been a major red herring for understanding their evolution. It's really good to have some hard data showing that some echinoderms exhibit some oddities that are not representative of all echinoderms."

The Hox cluster is a classic example of an 'evo-devo' genetic toolkit. The term "evo-devo" refers to the study of genetic programs that control development, which can be compared between species, and thus, across evolutionary time. 

The Hox genes coordinate segmental identity along the head to tail (anterior-posterior) axis. The Hox cluster is evolutionarily conserved and has been 

repurposed repeatedly during the evolution of the animal body plan, or how animals are shaped. Past studies have shown that Hox clusters organize the development of brain and central nervous system regions in chordates, limb bud identity in vertebrates, and, classically, antennae or wing segment identity in fruit flies.

Generally, the Hox cluster shows "colinearity," in which gene order correlates with the location of expression, or the developmental stage of expression. "For example, anterior Hox genes are expressed in regions that are closer to the head of an embryo, and are expressed sooner during development, versus the posterior Hox genes," explained Baughman. "Thus, we were surprised to see chordate-like Hox cluster organization in starfish, which have a radial body plan." Echinoderms are classical model organisms for embryology, and more recently evo-devo. Baughman added, "Interacting with the speakers and students of theOIST Winter Course 'Evolution of Complex Systems' (OWECS) allowed me to appreciate the importance of finding an intact Hox cluster in starfish."

The Crown of Thorns starfish, a predatory starfish which feeds on corals, is famous for its dramatic changes in population density on the reefs near Australia, as well as Okinawa. Over the past 50 years, this has resulted in a measurable loss of coral reefs. A recent 27-year reef monitoring study of the Great Barrier Reef estimated that the starfish accounts for 42% of the loss in coral cover, 2nd only to typhoons. While population control was the initial motivation for Crown of Thorns genome research, the Hox cluster report is one of the first to show that the species can be useful for studies in evolutionary-developmental biology. "We were excited to see the entire Hox cluster on a single genomic scaffold, a result which confirmed the remarkably high quality of the genomic data," said Prof. Satoh.

As is often the case with science, the discovery raises more questions than it answers. If starfish have a collinear Hox cluster, what accounts for their dramatic departures in body plan organization? Do starfish express Hox genes during development in a manner similar to chordates, as indicated by the organization of their Hox cluster? Baughman looks forward to addressing these questions and many more as part of his doctoral research. "I look forward to pursuing developmental biology studies that may suggest methods for mitigating damage to the coral reef caused by the Crown of Thorns starfish."

More research is being conducted at OIST on the Crown of Thorns starfish in the Marine Biophysics Unit by Masako Nakamura in cooperation with local fishermen. In addition to the research collaboration highlighted by the Hox publication, recent efforts by the Okinawa Prefectural Government and Australian Institute of Marine Science are also working on projects to protect the existing coral reefs from the Crown of Thorns starfish.

Source: Okinawa Institute of Science and Technology - OIST

Findings at viking archaeological site show power trumping practicality

Baylor archeologist Davide Zori and assistant at Viking farmstead. Credit: Image courtesy of Baylor University

Vikings are known for raiding and trading, but those who settled in Iceland centuries ago spent more time producing and consuming booze and beef -- in part to gain political clout in a place very different from their Scandinavian homeland, says a Baylor University archaeologist.

The seafaring warriors wanted to sustain the "big man" society of Scandinavia -- a political economy in which chieftains hosted huge feasts of beer and beef served in great halls, says Davide Zori, Ph.D., a Denmark native and archeological field director in Iceland, who conducted National Science Foundation-funded research in archeology and medieval Viking literature.
But instead, what Zori and his team discovered is what happened when the Vikings spent too long living too high on the hog -- or, in this case, the bovine. 

"It was somewhat like the barbecue here. You wanted a big steak on the grill," said Zori, assistant professor in the Baylor Interdisciplinary Core. He co-edited the book Viking Archaeology in Iceland: Mosfell Archaelogical Project with Jesse Byock, Ph.D., professor of Old Norse and medieval Scandinavian studies at the University of California, Los Angeles.

"It made it really showy -- if you could keep it up." The Viking chieftains used such wealth and cultural displays to flex political muscle with equals or rivals -- plus to cement good relations with local laborers, Zori said.

Zori and Byock's team excavated a farmstead called Hrísbrú in Iceland's Mosfell Valley. The farm -- inhabited by some of the most famous Vikings of the Icelandic sagas -- included a chieftain's longhouse nearly 100 feet long with a "feast-worthy" great hall, a church and a cemetery of 26 graves indicating a mix of pagan and Christian traditions. Males sometimes were buried with ship remnants rather than in the simpler Christian manner of leaving earthly possessions behind.

Carbon dating and studies of volcanic layers indicate the longhouse was built in the late ninth or early 10th century and abandoned by the 11th. The archeological team uncovered 38 layers of floor ash, including refuse dumped atop the abandoned house, also discovering bones, barley seeds and valuable glass beads imported from Asia. "By applying anthropology and medieval texts, we can excavate and compare," Zori said.

Viking sagas, first written in the 13th century and based on oral accounts, included such details as where people sat at feasts, "which shows your ranking . . . These texts read almost like novels. They're incredible sources. They talk about daily life," Zori said.

"Yes, the Vikings may have put axes to one another's heads -- but these accounts also describe milking cows."

High Times and Hard Times

When the Vikings arrived in uninhabited Iceland, they found forested lowlands, ample pastures and sheltered sea inlets. Excavations show that choice cattle were selected for feasts, with ritual slaughter and display of skulls, according to research published by Zori and others in the journal Antiquity. Barley seeds unearthed from floors or refuse heaps indicate barley consumption, and pollen studies demonstrate barley cultivation. Barley could have been used for bread or porridge, but beer's social value makes it very likely barley was used mainly to produce alcohol, Zori said.

Over centuries, as temperatures in the North Atlantic dropped during the "Little Ice Age," being a lavish host got tougher. "Nine months of winter -- and three months that are only a little less than winter," Zori said.

While sheep could find food free range most of the year and were suited for cold, prized cattle had to be kept indoors in large barns during the winter. Savvy supply-and-demand reckoning was crucial to be sure the food lasted -- both for cattle and humans -- and could be preserved.

"They had to decide how many to slaughter and store," Zori said. "They didn't have salt, so they had to use big vats of curdled milk as a preservative." As the landscape changed due to erosion, climate shifts and cleared forests, it became harder to rear larger numbers of cattle.

High-status households also struggled to grow enough grain for beer-making, based on historical accounts and confirmed by a growing body of archeological data. With a shorter growing season and colder climate than in their homelands, Icelandic Vikings would have needed more laborers to improve the soil -- and as the chieftains' power waned, they would have had trouble attracting workers. As barley cultivation stopped, the local chieftains are no longer mentioned in the Viking sagas.

Changing Directions

"You can see in the archeological evidence that they adjusted their strategy and gave it up eventually," Zori said. "It got harder and harder to keep up that showiness -- and when that collapsed, you didn't have that power, that beer and big slabs of beef to show off."

When barley was abandoned, the pollen record shows native grasses for grazing increased. Archeological findings show that the proportion of cattle to sheep bones declined, as Hrísbrú residents shifted to more practical, less laborious sheep-herding.

"You wonder what came first for the chieftains at Hrísbrú: Were they no longer powerful and didn't need barley and beef? Or could they just not keep it up and so they lost power? I favor the second explanation," Zori said.

"What we're doing now is to let the archaeology speak, both for itself and for proof to verify (the texts)," he said. "Investigating politics breathes life into it, instead of just saying, 'Here are three rocks.' You can ask deeper questions."
Zori argues that Viking chieftains' drive to produce expensive beef and beer caused them to put their political aspirations above the greater good of the community.

"Maybe we don't need the Vikings to prove this," he said. "But it shows you that politics can become more important than creating a productive society."

Source: Baylor University

Were Neanderthals a sub-species of modern humans? New research says no

Depiction of Neanderthal (stock image). Credit: © procy_ab / Fotolia

In an extensive, multi-institution study led by SUNY Downstate Medical Center, researchers have identified new evidence supporting the growing belief that Neanderthals were a distinct species separate from modern humans (Homo sapiens), and not a subspecies of modern humans.

The study looked at the entire nasal complex of Neanderthals and involved researchers with diverse academic backgrounds. Supported by funding from the National Science Foundation and the National Institutes of Health, the research also indicates that the Neanderthal nasal complex was not adaptively inferior to that of modern humans, and that the Neanderthals' extinction was likely due to competition from modern humans and not an inability of the Neanderthal nose to process a colder and drier climate.

Samuel Márquez, PhD, associate professor and co-discipline director of gross anatomy in SUNY Downstate's Department of Cell Biology, and his team of specialists published their findings on the Neanderthal nasal complex in the November issue of The Anatomical Record, which is part of a special issue on The Vertebrate Nose: Evolution, Structure, and Function (now online).

They argue that studies of the Neanderthal nose, which have spanned over a century and a half, have been approaching this anatomical enigma from the wrong perspective. Previous work has compared Neanderthal nasal dimensions to modern human populations such as the Inuit and modern Europeans, whose nasal complexes are adapted to cold and temperate climates.

However, the current study joins a growing body of evidence that the upper respiratory tracts of this extinct group functioned via a different set of rules as a result of a separate evolutionary history and overall cranial bauplan (bodyplan), resulting in a mosaic of features not found among any population of Homo sapiens. Thus Dr. Márquez and his team of paleoanthropologists, comparative anatomists, and an otolaryngologist have contributed to the understanding of two of the most controversial topics in paleoanthropology -- were Neanderthals a different species from modern humans and which aspects of their cranial morphology evolved as adaptations to cold stress.

"The strategy was to have a comprehensive examination of the nasal region of diverse modern human population groups and then compare the data with the fossil evidence. We used traditional morphometrics, geometric morphometric methodology based on 3D coordinate data, and CT imaging," Dr. Márquez explained.

Anthony S. Pagano, PhD, anatomy instructor at NYU Langone Medical Center, a co-author, traveled to many European museums carrying a microscribe digitizer, the instrument used to collect 3D coordinate data from the fossils studied in this work, as spatial information may be missed using traditional morphometric methods. "We interpreted our findings using the different strengths of the team members," Dr. Márquez said, "so that we can have a 'feel' for where these Neanderthals may lie along the modern human spectrum."

Co-author William Lawson, MD, DDS, vice-chair and the Eugen Grabscheid research professor of otolaryngology and director of the Paleorhinology Laboratory of the Icahn School of Medicine at Mount Sinai, notes that the external nasal aperture of the Neanderthals approximates some modern human populations but that their midfacial prognathism (protrusion of the midface) is startlingly different. That difference is one of a number of Neanderthal nasal traits suggesting an evolutionary development distinct from that of modern humans. Dr. Lawson's conclusion is predicated upon nearly four decades of clinical practice, in which he has seen over 7,000 patients representing a rich diversity of human nasal anatomy.

Distinguished Professor Jeffrey T. Laitman, PhD, also of the Icahn School of Medicine and director of the Center for Anatomy and Functional Morphology, and Eric Delson, PhD, director of the New York Consortium in Evolutionary Primatology or NYCEP, are also co-authors and are seasoned paleoanthropologists, each approaching their fifth decade of studying Neanderthals. Dr. Delson has published on various aspects of human evolution since the early 1970's.

Dr. Laitman states that this article is a significant contribution to the question of Neanderthal cold adaptation in the nasal region, especially in its identification of a different mosaic of features than those of cold-adapted modern humans. Dr. Laitman's body of work has shown that there are clear differences in the vocal tract proportions of these fossil humans when compared to modern humans. This current contribution has now identified potentially species-level differences in nasal structure and function.

Dr. Laitman said, "The strength of this new research lies in its taking the totality of the Neanderthal nasal complex into account, rather than looking at a single feature. By looking at the complete morphological pattern, we can conclude that Neanderthals are our close relatives, but they are not us."

Ian Tattersall, PhD, emeritus curator of the Division of Anthropology at the American Museum of Natural History, an expert on Neanderthal anatomy and functional morphology who did not participate in this study, stated, "Márquez and colleagues have carried out a most provocative and intriguing investigation of a very significant complex in the Neanderthal skull that has all too frequently been overlooked." Dr. Tattersall hopes that "with luck, this research will stimulate future research demonstrating once and for all that Homo neanderthalensis deserves a distinctive identity of its own."

Source: SUNY Downstate Medical Center

Ancient human genome from southern Africa throws light on our origins

Professor Vanessa Hayes in the field.

The skeleton of a man who lived 2,330 years ago in the southernmost tip of Africa tells us about ourselves as humans, and throws some light on our earliest common genetic ancestry.

What can DNA from the skeleton of a man who lived 2,330 years ago in the southernmost tip of Africa tell us about ourselves as humans? A great deal when his DNA profile is one of the 'earliest diverged' -- oldest in genetic terms -- found to-date in a region where modern humans are believed to have originated roughly 200,000 years ago.

The man's maternal DNA, or 'mitochondrial DNA', was sequenced to provide clues to early modern human prehistory and evolution. Mitochondrial DNA provided the first evidence that we all come from Africa, and helps us map a figurative genetic tree, all branches deriving from a common 'Mitochondrial Eve'.
When archaeologist Professor Andrew Smith from the University of Cape Town discovered the skeleton at St. Helena Bay in 2010, very close to the site where 117,000 year old human footprints had been found -- dubbed "Eve's footprints" -- he contacted Professor Vanessa Hayes, an expert in African genomes.

At the time, Hayes was Professor of Genomic Medicine at the J. Craig Venter Institute in San Diego, California. She now heads the Laboratory for Human Comparative and Prostate Cancer Genomics at Sydney's Garvan Institute of Medical Research.

The complete 1.5 metre tall skeleton was examined by Professor Alan Morris, from the University of Cape Town. A biological anthropologist, Morris showed that the man was a 'marine forager'. A bony growth in his ear canal, known as 'surfer's ear', suggested that he spent some time diving for food in the cold coastal waters, while shells carbon-dated to the same period, and found near his grave, confirmed his seafood diet. Osteoarthritis and tooth wear placed him in his fifties.

Due to the acidity of the soil within the region, acquiring DNA from skeletons has proven problematic. The Hayes team therefore worked with the world's leading laboratory in ancient DNA research, namely that of paleogeneticist Professor Svante Pääbo at the Max Planck Institute for Evolutionary Anthropolgy in Leipzig, Germany, who successfully sequenced a Neanderthal.

The team generated a complete mitochondrial genome, using DNA extracted from a tooth and a rib. The findings provided genomic evidence that this man, from a lineage now presumed extinct, as well as other indigenous coastal dwellers like him, were the most closely related to 'Mitochondrial Eve'.

The study underlines the significance of southern African archaeological remains in defining human origins, and is published in the journal Genome Biology and Evolution, now online.

"We were thrilled that archaeologist Andrew Smith understood the importance of not touching the skeleton when he found it, and so did not contaminate its DNA with modern human DNA," said Professor Hayes.

"I approached Svante Pääbo because his lab is the best in the world at DNA extraction from ancient bones. This skeleton was very precious and we needed 
to make sure the sample was in safe hands."

"Alan Morris undertook some incredible detective work. He used his skills in forensics and murder cases to assemble a profile of the man behind the St Helena skeleton."

"Alan helped establish that this man was a marine hunter-gatherer -- in contrast to the contemporary inland hunter-gatherers from the Kalahari dessert. We were very curious to know how this man related to them."

"We also know that this man pre-dates migration into the region, which took place around 2,000 years ago when pastoralists made their way down the coast from Angola, bringing herds of sheep. We could demonstrate that our marine hunter-gatherer carried a different maternal lineage to these early migrants -- containing a DNA variant that we have never seen before."

"Because of this, the study gives a baseline against which historic herders at the Cape can now be compared."

While interested in African lineages, and how they interact with each other, Professor Hayes is especially keen for Africa to inform genomic research and medicine worldwide.

"One of the biggest issues at present is that no-one is assembling genomes from scratch -- in other words, when someone is sequenced, their genome is not pieced together as is," she said.

"Instead, sections of the sequenced genome are mapped to a reference genome. Largely biased by European contribution, the current reference is poorly representative of indigenous peoples globally."

"If we want a good reference, we have to go back to our early human origins."
"None of us that walk on this planet now are pure anything -- we are all mixtures. For example 1-4% of Eurasians even carry Neanderthal DNA"

"We need more genomes that don't have extensive admixture. In other words, we need to reduce the noise."

"In this study, I believe we may have found an individual from a lineage that broke off early in modern human evolution and remained geographically isolated. That would contribute significantly to refining the human reference genome."

Source: Garvan Institute of Medical Research

Oldest stone tool ever found in Turkey discovered

Stone tool approximately 1.2 million years old. Credit: Image courtesy of University of Royal Holloway London

Scientists have discovered the oldest recorded stone tool ever to be found in Turkey, revealing that humans passed through the gateway from Asia to Europe much earlier than previously thought, approximately 1.2 million years ago.

According to research published in the journal Quaternary Science Reviews, the chance find of a humanly-worked quartzite flake, in ancient deposits of the river Gediz, in western Turkey, provides a major new insight into when and how early humans dispersed out of Africa and Asia.

Researchers from Royal Holloway, University of London, together with an international team from the UK, Turkey and the Netherlands, used high-precision equipment to date the deposits of the ancient river meander, giving the first accurate timeframe for when humans occupied the area.

Professor Danielle Schreve, from the Department of Geography at Royal Holloway, said: "This discovery is critical for establishing the timing and route of early human dispersal into Europe. Our research suggests that the flake is the earliest securely-dated artefact from Turkey ever recorded and was dropped on the floodplain by an early hominin well over a million years ago."

The researchers used high-precision radioisotopic dating and palaeomagnetic measurements from lava flows, which both pre-date and post-date the meander, to establish that early humans were present in the area between approximately 1.24 million and 1.17 million years ago. Previously, the oldest hominin fossils in western Turkey were recovered in 2007 at Koçabas, but the dating of these and other stone tool finds were uncertain.

"The flake was an incredibly exciting find," Professor Schreve said. "I had been studying the sediments in the meander bend and my eye was drawn to a pinkish stone on the surface. When I turned it over for a better look, the features of a humanly-struck artefact were immediately apparent.

"By working together with geologists and dating specialists, we have been able to put a secure chronology to this find and shed new light on the behaviour of our most distant ancestors."

Source: University of Royal Holloway London

Parasites and the evolution of primate culture

Chimpanzees (stock image). A new study examines the ‘costs’ of innovation, and learning from others. Credit: © shiruikage / Fotolia

Learning from others and innovation have undoubtedly helped advance civilization. But these behaviours can carry costs as well as benefits. And a new study by an international team of evolutionary biologists sheds light on how one particular cost -- increased exposure to parasites -- may affect cultural evolution in non-human primates.

The results, published Dec. 3, 2014 in the journal Proceedings of the Royal Society B, suggest that species with members that learn from others suffer from a wider variety of socially transmitted parasites, while innovative, exploratory species suffer from a wider variety of parasites transmitted through the environment, such as in the soil or water.

"We tend to focus on innovation and learning from others as a good thing, but their costs have received relatively little attention," says McGill University biologist Simon Reader, co-author of the study. "Here, we uncover evidence that socially transmitted pathogen burdens rise with learning from others -- perhaps because close interaction is needed for such learning -- and environmentally transmitted pathogen burdens rise with exploratory behaviour such as innovation and extractive foraging."

Chimpanzees, for example, live in groups and have a wide range of such behaviours, such as digging for food underground or eating new kinds of insects.. Previously, studies have not been able to determine whether costly parasites force primates to engage in more exploratory behaviour -- by diversifying food sources, for example -- or whether exploratory behaviour leads to their having more parasites, Reader notes. "Our results support the idea that exploratory and social behaviours expose primates to specific kinds of parasites."

"The findings also lead to questions about how people and other primates have developed solutions to minimize these parasite costs -- such as eating medicinal plants -- and may help us better understand how the processes underlying human culture arose," Reader says.
The research team, led by Collin McCabe of Harvard University and Charles Nunn of Duke University, based their analyses on databases obtained by surveying thousands of articles on primate behaviour and parasites.

Funding for the research was provided by the National Science Foundation, the Natural Sciences and Engineering Research Council of Canada, and the Netherlands Organisation for Scientific Research.

Source: McGill University

Using power of computers to harness human genome may provide clues into Ebola virus

Ramaswamy Narayanan, Ph.D., professor in the Charles E. Schmidt College of Science at Florida Atlantic University.

Ramaswamy Narayanan, Ph.D., professor in the Charles E. Schmidt College of Science at Florida Atlantic University, is working to blend the power of computers with biology to use the human genome to remove much of the guesswork involved in discovering cures for diseases.

In an article titled "Ebola-Associated Genes in the Human Genome: Implications for Novel Targets," published in the current MedCrave Online Journal of Proteomics and Bioinformatics, Narayanan describes how key genes that are present in our cells could be used to develop drugs for this disease.

"Bioinformatics is a powerful tool to help us understand biological data," said Narayanan whose research has focused in this field for more than a decade. "We are mining the human genome for Ebola virus association to develop an understanding of the human proteins involved in this disease for subsequent research and development, and to potentially create a pipeline of targets that we can test and evaluate."

Ebola virus disease is a major healthcare challenge facing the globe today and if left unchecked could become a pandemic. A limited knowledgebase exists about the Ebola virus and companies are hastening to develop vaccines and other forms to treat and cure the virus. There are no FDA-approved drugs, and developing vaccines or antibodies and testing them in clinical trials is an arduous process that takes considerable time. Currently, patients infected with Ebola are only able to receive supportive care such as fluid replacement, nutritional support, pain control, and blood pressure maintenance. In some cases, patients may be fortunate enough to be treated with experimental drugs.

Narayanan's work has helped to identify numerous FDA-approved drugs already used for many other diseases including anti-inflammatory drugs, anticoagulants, cancer, HIV, statins and hormones, which could potentially be used to add to the current supportive care for patients with the Ebola virus.

"With the high mortality rate of this disease, the world urgently needs new ways to treat patients," said Narayanan. "The ability to use drugs that are already approved by the FDA could provide clinicians with more options to treat Ebola patients, rather than just relying on supportive measures like fluid replacement or antibiotics."

According to the World Health Organization (WHO), Ebola virus disease (EVD) is a severe, often fatal illness in humans. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmissions. The evolving knowledge of this disease is prompting appropriate attention locally and globally. The 2014 Ebola epidemic has affected multiple countries in West Africa with some cases observed in Europe and the United States.

Source: Florida Atlantic University