The 500 million years ocean history

Brachiopod Paraspirifer bownockeri from the Middle Devonian of Ohio (USA); Width: 5.6 cm. Picture: U. Jansen, Senckenberg Museum, Frankfurt am Main.

GEOMAR coordinates European research and education project BASE-LiNE Earth
02.03.2015 / Kiel. As the history of the oceans can be reconstructed in the past 500 million based on calcareous shells of fossil marine life, busy to date with the research project BASE-LiNE Earth. At the same time it enables talented young scientists and scientists a doctorate in an international research environment. The European Union supports the at GEOMAR Helmholtz Centre for Ocean Research Kiel coordinated project with a total of 3.8 million euros.

Almost all life on earth would be extinct - and that at least five times in the past 500 million years. The environmental changes that have each led to the mass extinction, the oceans play an important role in almost all cases. How did it happen that was phased so hostile to life as a life-giving force sea? And why have some species still survive? These are fundamental questions that will be examined in the next three years as part of the European research project BASE-LiNE Earth with innovative technologies and methods. In addition to answering the research questions BASE LiNE Earth serves as the training of talented young scholars and scientists who are recruited by means of a demanding selection process from all over the world and doctorate within the scope of the project. 

The EU promotes the GEOMAR Helmholtz Centre for Ocean Research Kiel coordinated project under a Marie Skłodowska-Curie Action in Horizon2020-Pogramm with a total of 3.8 million euros. The challenge for the future BASE-LiNE Earth-doctoral students, is to provide information to gain from distant epochs of earth's history. "When historians want to know about events 100 or 200 years ago, they visit libraries or archives where there is written evidence from these times," says project coordinator Prof. Dr. Anton Eisenhauer from GEOMAR. "We also use archives. 
However, they see something different. It is, for example, the calcareous shells of fossil brachiopods in which the relevant data on the chemical history of ocean water are stored reliably, "explains the Kiel geochemist on. 

The information is in the calcite shells of course not writing before, but encrypted in the chemical and mineralogical composition. "If we precise the ratios of elements such as strontium, magnesium, boron, or measure of the isotopic to each other, we can decrypt the information," says Professor Eisenhauer.

This then the age of the shell, as well as the chemical composition of the previous ocean and prevailing environmental conditions such as water temperature and the acidity of the water can be reconstructed. We know, for example, know that during the greatest mass extinction 251 million years ago, the ocean contained no oxygen and was acidified to a large extent. 

"This is similar to some scenarios that we expect for the future of our ocean," explains Professor Eisenhauer. Model calculations are carried out within the framework of the project should show how far the former changes in the environment are transferable to the present day. The challenge is to gain this information and to make it usable. In collaboration with industry partners modern analytical methods for obtaining information in cooperation with business partners in this area in the context of BASE-LiNE Earth therefore be generated and developed. The project involves a total of 21 scientific institutions from eight European countries and partners from Canada, Israel, Palestine and Australia involved. 15 PhD positions will announce the project this spring, two of them for the GEOMAR in Kiel. 

The Integrated School of Ocean Sciences (ISOS) provides at the University of Kiel for a comprehensive training program in which the scholars not only pursue their academic goals, but also learn more professional qualifications, skills and interact with each other.  In the coming years, the parties want to do their topic also by means of exhibitions and school supplies to a wider audience. "Of course we also bind the doctoral students, which thus also learn to communicate their work understandable," says the project coordinator. For more information on the project website www.baseline-earth.eu.

Source: Geomar

A Long dry spell doomed Mexican city 1,000 years ago

Ruins of the city of Cantona in the Mexican state of Puebla, with the mountain Cerro Pizarro in the background. The city was abandoned almost 1,000 years ago, probably as a result of a prolonged dry spell. (Ines Urdaneta image courtesy of Wikimedia Commons.)

A UC Berkeley study sheds new light on this question, providing evidence that a prolonged period of below-average rainfall was partly responsible for the abandonment of one such city, Cantona, between A.D. 900 and A.D. 1050.

At its peak, Cantona, located in a dry, volcanic basin (La Cuenca Oriental) east of today’s Mexico City, was one of the largest cities in the New World, with 90,000 inhabitants. The area was a major source of obsidian, and the city may have played a military role alongside an important trade route from the Veracruz coast into the highlands.

To assess the climate in that area before and after Cantona’s collapse, UC Berkeley geographers analyzed sediment cores from a lake located 20 miles south of the former city. They found evidence of a 650-year period of frequent droughts that extended from around A.D. 500 to about A.D. 1150. This was part of a long-term drying trend in highland Mexico that started 2,200 years ago, around 200 B.C. The climate became wetter again in about A.D. 1300, just prior to the rise of the Aztec empire.

“The decline of Cantona occurred during this dry interval, and we conclude that climate change probably played a role, at least towards the end of the city’s existence,” said lead author Tripti Bhattacharya, a UC Berkeley graduate student.

Surprisingly, the population of Cantona increased during the early part of the dry period, perhaps because of political upheaval elsewhere that increased the importance of the heavily fortified city, she said. Teotihuacan, less than 100 miles to the west, was in decline at the time, also possibly because of more frequent droughts. 

Lake Aljojuca, Mexico
The maar lake Aljojuca, 20 miles south of Cantona, yielded sediments that recorded a lengthy series of droughts between A.D. 500 and 1150. (Tripti Bhattacharya photo)

“In a sense the area became important because of the increased frequency of drought,” said UC Berkeley associate professor of geography Roger Byrne. “But when the droughts continued on such a scale, the subsistence base for the whole area changed and people just had to leave. The city was abandoned.”

Bhattacharya, Byrne and their colleagues report their findings in an article appearing this week in the early edition of the journal Proceedings of the National Academy of Sciences. The UC Berkeley researchers analyzed lake cores provided by scientists at the National Autonomous University of Mexico in Juriquilla, Querétaro, Mexico and the German Research Centre for Geosciences in Potsdam, Germany.

Political upheaval and climate change

Byrne emphasized that the area’s typical monsoon weather with wet summers and dry winters did not stop, but was interrupted by frequent short-term droughts, no doubt affecting crops and water supplies. Today the area is close to the northern limit of maize production without irrigation, and would have been particularly vulnerable to drier conditions, he said.

Byrne, a member of the Berkeley Initiative on Global Change Biology (BiGCB) and curator of fossil pollen in the Museum of Paleontology, has studied sediment cores from many lakes in Mexico and California, and is particularly interested in possible links between climate change and human activities.

Nearly 20 years ago, he learned of Cantona and traveled with students to the areas three times to obtain cores from lakes near the site, most of which are maar lakes created by magma explosions. They are deep and often contain undisturbed and regularly layered sediments ideal for chronological studies.

Tripti Bhattacharya
Tripti Bhattacharya analyzed carbonates in lake sediments to explore the climate history of the Cuenca Oriental east of Mexico City. (Ellie Broadman photo)

German colleagues cored this particular lake, Aljojuca, in 2007, and Bhattacharya traveled to Potsdam to collect sediment samples. Oxygen isotope ratios in carbonate sediments are correlated with the ratio of precipitation to evaporation and thus indicate aridity. Organic material in the sediments was used for accelerator mass spectroscopy carbon-14 dating.

“We can show that both the growth and decline of the site took place during a time period of frequent drought, which forces us to think in more nuanced ways about how political and social factors interact with environmental factors to cause social and cultural change,” Bhattacharya said. “That makes the study particularly interesting.”

Bhattacharya noted that more studies are necessary to reconstruct the prehistoric climate of highland Mexico. Such studies could reveal the causes of prehistoric climatic change and whether they were similar to the factors that regulate the region’s climate today, such as the El Niño/Southern Oscillation.

Co-authors include Harald Böhnel and Kurt Wogau of UNAM, Juriquilla; Ulrike Kienel of the German Research Center for Geosciences in Potsdam; B. Lynn Ingram of UC Berkeley; and Susan Zimmerman of Lawrence Livermore National Laboratory. The work was funded by the National Science Foundation.

Source: UC Berkeley

SETTLING FOR ‘MR. RIGHT NOW’ BETTER THAN WAITING FOR ‘MR. RIGHT’

Evolutionary researchers have determined that settling for “Mr. Okay” is a better evolutionary strategy than waiting for “Mr. Perfect.” When studying the evolution of risk aversion researchers found that it is in our nature – traced back to the earliest humans – to take the safe bet when stakes are high, such as whether or not we will mate. Photo by D.L. Turner

Evolutionary researchers have determined that settling for “Mr. Okay” is a better evolutionary strategy than waiting for “Mr. Perfect.”

When studying the evolution of risk aversion, Michigan State University researchers found that it is in our nature – traced back to the earliest humans – to take the safe bet when stakes are high, such as whether or not we will mate.

“Primitive humans were likely forced to bet on whether or not they could find a better mate,” said Chris Adami, MSU professor of microbiology and molecular genetics and co-author of the paper.

“They could either choose to mate with the first, potentially inferior, companion and risk inferior offspring, or they could wait for Mr. or Ms. Perfect to come around,” he said. “If they chose to wait, they risk never mating.”

Adami and his co-author Arend Hintze, MSU research associate, used a computational model to trace risk-taking behaviors through thousands of generations of evolution with digital organisms. These organisms were programmed to make bets in high-payoff gambles, which reflect the life-altering decisions that natural organisms must make, as for example choosing a mate.

“An individual might hold out to find the perfect mate but run the risk of coming up empty and leaving no progeny,” Adami said. “Settling early for the sure bet gives you an evolutionary advantage, if living in a small group.”

Adami and his team tested many variables that influence risk-taking behavior and concluded that certain conditions influence our decision-making process. The decision must be a rare, once-in-a-lifetime event and also have a high payoff for the individual’s future – such as the odds of producing offspring.

How risk averse we are correlates to the size of the group in which we were raised. If reared in a small group – fewer than 150 people – we tend to be much more risk averse than those who were part of a larger community.

It turns out that primitive humans lived in smaller groups, about 150 individuals. Because resources tend to be more scarce in smaller communities, this environment helps promote risk aversion.

“We found that it is really the group size, not the total population size, which matters in the evolution of risk aversion,” Hintze said.

However, not everyone develops the same level of aversion to risk. The study also found that evolution doesn’t prefer one single, optimal way of dealing with risk, but instead allows for a range of less, and sometimes more-risky, behaviors to evolve.

“We do not all evolve to be the same,” Adami said. “Evolution creates a diversity in our acceptance of risk, so you see some people who are more likely to take bigger risks than others. We see the same phenomenon in our simulations.”

The research was part of an interdisciplinary collaboration with Ralph Hertwig of the Max Planck Institute for Human Development in Berlin.

Also contributing to the study was Randal Olson, graduate student, MSU Department of Computer Science and Engineering and BEACON Center for the Study of Evolution in Action.

Source: Michigan State University

Skull sheds light on human-Neanderthal relationship

Retrieved from a cave in northern Israel, the partial skull provides the first evidence that Homo sapiens inhabited that region at the same time as Neanderthals. (Reuters: Nikola Solic)

A partial skull, found in a cave in Israel, is shedding light on the pivotal moment in early human history when our species left Africa and encountered our close cousins the Neanderthals.

Anthropologist Israel Hershkovitz, from Tel Aviv University, called the skull "an important piece of the puzzle of the big story of human evolution."

The findings of the research, led by Hershkovitz, are published today in the journal Nature.

The upper part of the skull - the domed portion without the face or jaws - was unearthed in Manot Cave in Israel's Western Galilee.

Scientific dating techniques determined the skull was about 55,000 years old, a time period when members of our species were thought to have been marching out of Africa,

The researchers say characteristics of the skull suggest the individual was closely related to the first Homo sapiens populations that later colonized Europe.

They also say the skull provides the first evidence that Homo sapiens inhabited that region at the same time as Neanderthals, our closest extinct human relative.

Previous genetic evidence suggests our species and Neanderthals interbred around the time the skull is dated to, with all people of Eurasian ancestry still retaining a small amount of Neanderthal DNA as a result.

"It is the first direct fossil evidence that modern humans and Neanderthals inhabited the same area at the same time," says palaeontologist Bruce Latimer of Case Western Reserve University in Cleveland, another of the researchers.

"The co-existence of these two populations in a confined geographic region at the same time that genetic models predict interbreeding promotes the notion that interbreeding may have occurred in the Levant region," Hershkovitz says.

The robust, large-browed Neanderthals prospered across Europe and Asia from about 350,000 to 40,000 years ago, going extinct sometime after Homo sapiens arrived.

Scientists say our species first appeared about 200,000 years ago in Africa and later migrated outwards. The cave is located along the sole land route for ancient humans to take from Africa into the Middle East, Asia and Europe.

Latimer says he suspects the skull belonged to a woman, although the researchers could not say definitively.

The cave, sealed off for 30,000 years, was discovered in 2008 during sewage line construction work. Hunting tools, perforated seashells perhaps used ornamentally and animal bones have been excavated from the cave, along with further human remains.

Source: ABC

Blazing car murder of 1930 investigated

Slide with Blazing Car victim's sample on it. Sample taken by Sir Bernard Spilsbury.
Credit: University of Leicester

University of Leicester leads collaboration with Northumbria University, Northamptonshire Police and The Royal London Hospital Museum, in investigation of the Blazing Car Murder of 1930

A forensic team from the University of Leicester and Northumbria University has spearheaded an investigation which has shed new light on a murder case from 1930.

A team from the University of Leicester, led by Dr John Bond OBE from the Department of Chemistry and Dr Lisa Smith from the Department of Criminology worked with colleagues from Northumbria University, Northamptonshire Police and The Royal London Hospital Museum to tackle the riddle of the 'Blazing Car Murder' from over 80 years ago.

The case involved the murder of a male in a car fire in Hardingstone, Northamptonshire, on 6 November 1930. Alfred Rouse was convicted, and later hanged, at Bedford Gaol in March 1931, for murdering his victim who to this day, has not been identified.

At the time, a post mortem examination was carried out in the garage of the local public house by the Home Office-appointed pathologist Sir Bernard Spilsbury, working alongside another local pathologist.

Sir Spilsbury reported that lavender coloured material and light brown hair were found at the scene. It was further documented that the victim's jawbone was removed to assist with possible identification and tissue samples taken for microscopical examination.

Two of these tissue samples are still in existence and archived in The Royal London Hospital Museum: one from the prostate to confirm the sex of the victim, and another from the lung to determine whether or not the victim was already dead before the fire was started.

In recent months, attention has turned to the fact that a man named William Briggs left his family home in London to attend a doctor's appointment at around the same time the crime was committed -- and was never seen or heard of again.

As part of their family ancestry research, the relatives of William Briggs wanted to verify earlier generations' belief that their ancestor may have been Rouse's car murder victim.

Last year, a number of William Briggs's relatives approached Northamptonshire Police in an attempt to put the 83-year-old mystery to rest and finally reveal the identity of the victim.

They met with the Force's curator and archivist Richard Cowley, discussed the story of the murder and were shown artefacts relating to the crime which, at the time received worldwide attention.

With the help of Northamptonshire Police, the family contacted University of Leicester academic Dr John Bond OBE. He and Dr Lisa Smith negotiated with The Royal London Hospital museum to allow one of the remaining tissue samples to be examined.

The slide was released with the approval of Professor Richard Trembath, at Queen Mary College University of London. The slide originates from the old Department of Forensic Medicine which formed part of The London Hospital Medical College. The College was merged with Queen Mary College in 1995.

The University of Leicester team considered whether there might just be enough mitochondrial DNA (mtDNA) left on the slide to get a profile to compare with mtDNA from the family.

Mitochondrial DNA is wholly inherited from the maternal line so it is essential to have an unbroken maternal line of descendants to test.

University of Leicester worked with the Northumbria University Centre for Forensic Science and Dr Eleanor Graham, a former member of staff at the University of Leicester, and Victoria Barlow to carry out DNA analysis on the samples to see if there was a match from the sample and the relatives.

Fortunately, the scientists obtained a full single male mtDNA profile from the slide to compare to the family.

Dr John Bond, from the University of Leicester said: "It's been very interesting and rewarding working on such a famous, local murder case. It was quite a unique investigation to be involved in, as the perpetrator had been identified long ago and brought to justice while the victim's identity remained unknown.

"It was a great example of how the scientific and criminological expertise at the University of Leicester and Northumbria University, working together with the police, could provide answers to this family after 83 years."

Detective Chief Superintendent Paul Phillips from Northamptonshire Police said: "From our perspective this is a closed case, the offender Alfred Rouse was convicted of murder and hanged, but this has been a long-standing mystery in Northamptonshire as the identity of the victim has never been established.

"Our work at Northamptonshire Police is victim focused so I was delighted to learn of new opportunities to establish the identity of the victim through the development of forensic science."

Dr Eleanor Graham from Northumbria University stated: "Projects such as this highlight the fact that forensic DNA analysis is not confined to 'catching criminals'. DNA analysis also has a critical role to play in the identification of those who have been killed during criminal acts, accidents or natural disasters, which have occurred recently, or many years ago."

The result is due to be revealed to the family on the BBC's The One Show on a date to be fixed.

Blazing Car Murder background:

Alfred Rouse sustained a head wound in the First World War, which left him with a personality disorder, to the point that he was described as 'a promiscuous rake with an enormous sexual appetite'.

Rouse was a commercial traveller who went all around the country and his promiscuous lifestyle resulted in him facing severe financial problems.

As a consequence, Rouse devised a plan to murder a homeless tramp who would not be missed by anyone which would enable him to stage his own death in a car accident and then disappear to start a new life free from financial restriction.

To that end, Rouse rendered his victim unconscious, placed him in the driver's seat of his car and set the car alight.

Rouse was making his way from the scene but bumped into two local youths keen to see what was going on and take part in some late Bonfire Night celebrations.

This initial contact eventually led to Rouse's arrest. He was convicted at Northampton Assizes and hanged in Bedford on 10 March 1931.

The local Herald newspaper suggested that the identity of Rouse's victim 'would likely remain a mystery forever.' But will it………..?

Source: University of Leicester

Were Neanderthals a sub-species of modern humans? New research says no

Depiction of Neanderthal (stock image). Credit: © procy_ab / Fotolia

In an extensive, multi-institution study led by SUNY Downstate Medical Center, researchers have identified new evidence supporting the growing belief that Neanderthals were a distinct species separate from modern humans (Homo sapiens), and not a subspecies of modern humans.

The study looked at the entire nasal complex of Neanderthals and involved researchers with diverse academic backgrounds. Supported by funding from the National Science Foundation and the National Institutes of Health, the research also indicates that the Neanderthal nasal complex was not adaptively inferior to that of modern humans, and that the Neanderthals' extinction was likely due to competition from modern humans and not an inability of the Neanderthal nose to process a colder and drier climate.

Samuel Márquez, PhD, associate professor and co-discipline director of gross anatomy in SUNY Downstate's Department of Cell Biology, and his team of specialists published their findings on the Neanderthal nasal complex in the November issue of The Anatomical Record, which is part of a special issue on The Vertebrate Nose: Evolution, Structure, and Function (now online).

They argue that studies of the Neanderthal nose, which have spanned over a century and a half, have been approaching this anatomical enigma from the wrong perspective. Previous work has compared Neanderthal nasal dimensions to modern human populations such as the Inuit and modern Europeans, whose nasal complexes are adapted to cold and temperate climates.

However, the current study joins a growing body of evidence that the upper respiratory tracts of this extinct group functioned via a different set of rules as a result of a separate evolutionary history and overall cranial bauplan (bodyplan), resulting in a mosaic of features not found among any population of Homo sapiens. Thus Dr. Márquez and his team of paleoanthropologists, comparative anatomists, and an otolaryngologist have contributed to the understanding of two of the most controversial topics in paleoanthropology -- were Neanderthals a different species from modern humans and which aspects of their cranial morphology evolved as adaptations to cold stress.

"The strategy was to have a comprehensive examination of the nasal region of diverse modern human population groups and then compare the data with the fossil evidence. We used traditional morphometrics, geometric morphometric methodology based on 3D coordinate data, and CT imaging," Dr. Márquez explained.

Anthony S. Pagano, PhD, anatomy instructor at NYU Langone Medical Center, a co-author, traveled to many European museums carrying a microscribe digitizer, the instrument used to collect 3D coordinate data from the fossils studied in this work, as spatial information may be missed using traditional morphometric methods. "We interpreted our findings using the different strengths of the team members," Dr. Márquez said, "so that we can have a 'feel' for where these Neanderthals may lie along the modern human spectrum."

Co-author William Lawson, MD, DDS, vice-chair and the Eugen Grabscheid research professor of otolaryngology and director of the Paleorhinology Laboratory of the Icahn School of Medicine at Mount Sinai, notes that the external nasal aperture of the Neanderthals approximates some modern human populations but that their midfacial prognathism (protrusion of the midface) is startlingly different. That difference is one of a number of Neanderthal nasal traits suggesting an evolutionary development distinct from that of modern humans. Dr. Lawson's conclusion is predicated upon nearly four decades of clinical practice, in which he has seen over 7,000 patients representing a rich diversity of human nasal anatomy.

Distinguished Professor Jeffrey T. Laitman, PhD, also of the Icahn School of Medicine and director of the Center for Anatomy and Functional Morphology, and Eric Delson, PhD, director of the New York Consortium in Evolutionary Primatology or NYCEP, are also co-authors and are seasoned paleoanthropologists, each approaching their fifth decade of studying Neanderthals. Dr. Delson has published on various aspects of human evolution since the early 1970's.

Dr. Laitman states that this article is a significant contribution to the question of Neanderthal cold adaptation in the nasal region, especially in its identification of a different mosaic of features than those of cold-adapted modern humans. Dr. Laitman's body of work has shown that there are clear differences in the vocal tract proportions of these fossil humans when compared to modern humans. This current contribution has now identified potentially species-level differences in nasal structure and function.

Dr. Laitman said, "The strength of this new research lies in its taking the totality of the Neanderthal nasal complex into account, rather than looking at a single feature. By looking at the complete morphological pattern, we can conclude that Neanderthals are our close relatives, but they are not us."

Ian Tattersall, PhD, emeritus curator of the Division of Anthropology at the American Museum of Natural History, an expert on Neanderthal anatomy and functional morphology who did not participate in this study, stated, "Márquez and colleagues have carried out a most provocative and intriguing investigation of a very significant complex in the Neanderthal skull that has all too frequently been overlooked." Dr. Tattersall hopes that "with luck, this research will stimulate future research demonstrating once and for all that Homo neanderthalensis deserves a distinctive identity of its own."

Source: SUNY Downstate Medical Center

Ancient human genome from southern Africa throws light on our origins

Professor Vanessa Hayes in the field.

The skeleton of a man who lived 2,330 years ago in the southernmost tip of Africa tells us about ourselves as humans, and throws some light on our earliest common genetic ancestry.

What can DNA from the skeleton of a man who lived 2,330 years ago in the southernmost tip of Africa tell us about ourselves as humans? A great deal when his DNA profile is one of the 'earliest diverged' -- oldest in genetic terms -- found to-date in a region where modern humans are believed to have originated roughly 200,000 years ago.

The man's maternal DNA, or 'mitochondrial DNA', was sequenced to provide clues to early modern human prehistory and evolution. Mitochondrial DNA provided the first evidence that we all come from Africa, and helps us map a figurative genetic tree, all branches deriving from a common 'Mitochondrial Eve'.
When archaeologist Professor Andrew Smith from the University of Cape Town discovered the skeleton at St. Helena Bay in 2010, very close to the site where 117,000 year old human footprints had been found -- dubbed "Eve's footprints" -- he contacted Professor Vanessa Hayes, an expert in African genomes.

At the time, Hayes was Professor of Genomic Medicine at the J. Craig Venter Institute in San Diego, California. She now heads the Laboratory for Human Comparative and Prostate Cancer Genomics at Sydney's Garvan Institute of Medical Research.

The complete 1.5 metre tall skeleton was examined by Professor Alan Morris, from the University of Cape Town. A biological anthropologist, Morris showed that the man was a 'marine forager'. A bony growth in his ear canal, known as 'surfer's ear', suggested that he spent some time diving for food in the cold coastal waters, while shells carbon-dated to the same period, and found near his grave, confirmed his seafood diet. Osteoarthritis and tooth wear placed him in his fifties.

Due to the acidity of the soil within the region, acquiring DNA from skeletons has proven problematic. The Hayes team therefore worked with the world's leading laboratory in ancient DNA research, namely that of paleogeneticist Professor Svante Pääbo at the Max Planck Institute for Evolutionary Anthropolgy in Leipzig, Germany, who successfully sequenced a Neanderthal.

The team generated a complete mitochondrial genome, using DNA extracted from a tooth and a rib. The findings provided genomic evidence that this man, from a lineage now presumed extinct, as well as other indigenous coastal dwellers like him, were the most closely related to 'Mitochondrial Eve'.

The study underlines the significance of southern African archaeological remains in defining human origins, and is published in the journal Genome Biology and Evolution, now online.

"We were thrilled that archaeologist Andrew Smith understood the importance of not touching the skeleton when he found it, and so did not contaminate its DNA with modern human DNA," said Professor Hayes.

"I approached Svante Pääbo because his lab is the best in the world at DNA extraction from ancient bones. This skeleton was very precious and we needed 
to make sure the sample was in safe hands."

"Alan Morris undertook some incredible detective work. He used his skills in forensics and murder cases to assemble a profile of the man behind the St Helena skeleton."

"Alan helped establish that this man was a marine hunter-gatherer -- in contrast to the contemporary inland hunter-gatherers from the Kalahari dessert. We were very curious to know how this man related to them."

"We also know that this man pre-dates migration into the region, which took place around 2,000 years ago when pastoralists made their way down the coast from Angola, bringing herds of sheep. We could demonstrate that our marine hunter-gatherer carried a different maternal lineage to these early migrants -- containing a DNA variant that we have never seen before."

"Because of this, the study gives a baseline against which historic herders at the Cape can now be compared."

While interested in African lineages, and how they interact with each other, Professor Hayes is especially keen for Africa to inform genomic research and medicine worldwide.

"One of the biggest issues at present is that no-one is assembling genomes from scratch -- in other words, when someone is sequenced, their genome is not pieced together as is," she said.

"Instead, sections of the sequenced genome are mapped to a reference genome. Largely biased by European contribution, the current reference is poorly representative of indigenous peoples globally."

"If we want a good reference, we have to go back to our early human origins."
"None of us that walk on this planet now are pure anything -- we are all mixtures. For example 1-4% of Eurasians even carry Neanderthal DNA"

"We need more genomes that don't have extensive admixture. In other words, we need to reduce the noise."

"In this study, I believe we may have found an individual from a lineage that broke off early in modern human evolution and remained geographically isolated. That would contribute significantly to refining the human reference genome."

Source: Garvan Institute of Medical Research

Human faces are so variable because we evolved to look unique

The amazing variety of human faces -- far greater than that of most other animals -- is the result of evolutionary pressure to make each of us unique and easily recognizable. Credit: UC Berkeley

The amazing variety of human faces -- far greater than that of most other animals -- is the result of evolutionary pressure to make each of us unique and easily recognizable, according to a new study by University of California, Berkeley, scientists.

Our highly visual social interactions are almost certainly the driver of this evolutionary trend, said behavioral ecologist Michael J. Sheehan, a postdoctoral fellow in UC Berkeley's Museum of Vertebrate Zoology. Many animals use smell or vocalization to identify individuals, making distinctive facial features unimportant, especially for animals that roam after dark, he said. But humans are different.

"Humans are phenomenally good at recognizing faces; there is a part of the brain specialized for that," Sheehan said. "Our study now shows that humans have been selected to be unique and easily recognizable. It is clearly beneficial for me to recognize others, but also beneficial for me to be recognizable. Otherwise, we would all look more similar."

"The idea that social interaction may have facilitated or led to selection for us to be individually recognizable implies that human social structure has driven the evolution of how we look," said coauthor Michael Nachman, a population geneticist, professor of integrative biology and director of the UC Berkeley Museum of Vertebrate Zoology.

The study will appear Sept. 16 in the online journal Nature Communications.

In the study, Sheehan said, "we asked, 'Are traits such as distance between the eyes or width of the nose variable just by chance, or has there been evolutionary selection to be more variable than they would be otherwise; more distinctive and more unique?'"

As predicted, the researchers found that facial traits are much more variable than other bodily traits, such as the length of the hand, and that facial traits are independent of other facial traits, unlike most body measures. People with longer arms, for example, typically have longer legs, while people with wider noses or widely spaced eyes don't have longer noses. Both findings suggest that facial variation has been enhanced through evolution.

Finally, they compared the genomes of people from around the world and found 

more genetic variation in the genomic regions that control facial characteristics than in other areas of the genome, a sign that variation is evolutionarily advantageous.

"All three predictions were met: facial traits are more variable and less correlated than other traits, and the genes that underlie them show higher levels of variation," Nachman said. "Lots of regions of the genome contribute to facial features, so you would expect the genetic variation to be subtle, and it is. But it is consistent and statistically significant."

Using Army data

Sheehan was able to assess human facial variability thanks to a U.S. Army database of body measurements compiled from male and female personnel in 1988. The Army Anthropometric Survey (ANSUR) data are used to design and size everything from uniforms and protective clothing to vehicles and workstations.

A statistical comparison of facial traits of European Americans and African Americans -- forehead-chin distance, ear height, nose width and distance between pupils, for example -- with other body traits -- forearm length, height at waist, etc. -- showed that facial traits are, on average, more varied than the others. The most variable traits are situated within the triangle of the eyes, mouth and nose.

Sheehan and Nachman also had access to data collected by the 1000 Genome project, which has sequenced more than 1,000 human genomes since 2008 and catalogued nearly 40 million genetic variations among humans worldwide. Looking at regions of the human genome that have been identified as determining the shape of the face, they found a much higher number of variants than for traits, such as height, not involving the face.

Prehistoric origins

"Genetic variation tends to be weeded out by natural selection in the case of traits that are essential to survival," Nachman said. "Here it is the opposite; selection is maintaining variation. All of this is consistent with the idea that there has been selection for variation to facilitate recognition of individuals."

They also compared the human genomes with recently sequenced genomes of Neanderthals and Denisovans and found similar genetic variation, which indicates that the facial variation in modern humans must have originated prior to the split between these different lineages.

"Clearly, we recognize people by many traits -- for example their height or their gait -- but our findings argue that the face is the predominant way we recognize people," Sheehan said.

Source: University of California - Berkeley

Oldest stone tool ever found in Turkey discovered

Stone tool approximately 1.2 million years old. Credit: Image courtesy of University of Royal Holloway London

Scientists have discovered the oldest recorded stone tool ever to be found in Turkey, revealing that humans passed through the gateway from Asia to Europe much earlier than previously thought, approximately 1.2 million years ago.

According to research published in the journal Quaternary Science Reviews, the chance find of a humanly-worked quartzite flake, in ancient deposits of the river Gediz, in western Turkey, provides a major new insight into when and how early humans dispersed out of Africa and Asia.

Researchers from Royal Holloway, University of London, together with an international team from the UK, Turkey and the Netherlands, used high-precision equipment to date the deposits of the ancient river meander, giving the first accurate timeframe for when humans occupied the area.

Professor Danielle Schreve, from the Department of Geography at Royal Holloway, said: "This discovery is critical for establishing the timing and route of early human dispersal into Europe. Our research suggests that the flake is the earliest securely-dated artefact from Turkey ever recorded and was dropped on the floodplain by an early hominin well over a million years ago."

The researchers used high-precision radioisotopic dating and palaeomagnetic measurements from lava flows, which both pre-date and post-date the meander, to establish that early humans were present in the area between approximately 1.24 million and 1.17 million years ago. Previously, the oldest hominin fossils in western Turkey were recovered in 2007 at Koçabas, but the dating of these and other stone tool finds were uncertain.

"The flake was an incredibly exciting find," Professor Schreve said. "I had been studying the sediments in the meander bend and my eye was drawn to a pinkish stone on the surface. When I turned it over for a better look, the features of a humanly-struck artefact were immediately apparent.

"By working together with geologists and dating specialists, we have been able to put a secure chronology to this find and shed new light on the behaviour of our most distant ancestors."

Source: University of Royal Holloway London

Using power of computers to harness human genome may provide clues into Ebola virus

Ramaswamy Narayanan, Ph.D., professor in the Charles E. Schmidt College of Science at Florida Atlantic University.

Ramaswamy Narayanan, Ph.D., professor in the Charles E. Schmidt College of Science at Florida Atlantic University, is working to blend the power of computers with biology to use the human genome to remove much of the guesswork involved in discovering cures for diseases.

In an article titled "Ebola-Associated Genes in the Human Genome: Implications for Novel Targets," published in the current MedCrave Online Journal of Proteomics and Bioinformatics, Narayanan describes how key genes that are present in our cells could be used to develop drugs for this disease.

"Bioinformatics is a powerful tool to help us understand biological data," said Narayanan whose research has focused in this field for more than a decade. "We are mining the human genome for Ebola virus association to develop an understanding of the human proteins involved in this disease for subsequent research and development, and to potentially create a pipeline of targets that we can test and evaluate."

Ebola virus disease is a major healthcare challenge facing the globe today and if left unchecked could become a pandemic. A limited knowledgebase exists about the Ebola virus and companies are hastening to develop vaccines and other forms to treat and cure the virus. There are no FDA-approved drugs, and developing vaccines or antibodies and testing them in clinical trials is an arduous process that takes considerable time. Currently, patients infected with Ebola are only able to receive supportive care such as fluid replacement, nutritional support, pain control, and blood pressure maintenance. In some cases, patients may be fortunate enough to be treated with experimental drugs.

Narayanan's work has helped to identify numerous FDA-approved drugs already used for many other diseases including anti-inflammatory drugs, anticoagulants, cancer, HIV, statins and hormones, which could potentially be used to add to the current supportive care for patients with the Ebola virus.

"With the high mortality rate of this disease, the world urgently needs new ways to treat patients," said Narayanan. "The ability to use drugs that are already approved by the FDA could provide clinicians with more options to treat Ebola patients, rather than just relying on supportive measures like fluid replacement or antibiotics."

According to the World Health Organization (WHO), Ebola virus disease (EVD) is a severe, often fatal illness in humans. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmissions. The evolving knowledge of this disease is prompting appropriate attention locally and globally. The 2014 Ebola epidemic has affected multiple countries in West Africa with some cases observed in Europe and the United States.

Source: Florida Atlantic University

Colorado's Front Range fire severity not much different than past

A new study indicates present-day forest fires on Colorado's Front Range are not significantly more intense than historical fires. Credit: Glenn Asakawa, University of Colorado

The perception that Colorado's Front Range wildfires are becoming increasingly severe does not hold much water scientifically, according to a massive new study led by the University of Colorado Boulder and Humboldt State University in Arcata, Calif.

The study authors, who looked at 1.3 million acres of ponderosa pine and mixed conifer forest from Teller County west of Colorado Springs through Larimer County west and north of Fort Collins, reconstructed the timing and severity of past fires using fire-scarred trees and tree-ring data going back to the 1600s. Only 16 percent of the study area showed a shift from historically low-severity fires to severe, potential crown fires that can jump from treetop to treetop.

The idea that modern fires are larger and more severe as a result of fire suppression that allowed forest fuels to build up in the past century is still prevalent among some, said CU-Boulder geography Professor Thomas Veblen, a study co-author. "The key point here is that modern fires in these Front Range forests are not radically different from the fire severity of the region prior to any effects of fire suppression," he said.

A paper on the subject was published Sept. 24 in the journal PLOS ONE. The study was led by Associate Professor Rosemary Sherriff of Humboldt State University and involved Research Scientist Tania Schoennagel of CU-Boulder's Institute of Arctic and Alpine Research, CU-Boulder doctoral student Meredith Gartner and Associate Professor Rutherford Platt of Gettysburg College in Gettysburg, Pa.

The study was funded by the National Science Foundation.

"The common assumption is that fires are now more severe and are killing higher percentages of trees," said Sherriff, who completed her doctorate at CU-Boulder under Veblen in 2004. "Our results show that this is not the case on the Front Range except for the lowest elevation forests and woodlands."

One important new finding comes from a comparison of nine large fires that have occurred on the Front Range since 2000 -- including the 2002 Hayman Fire southwest of Denver, the 2010 Fourmile Canyon Fire west of Boulder and the 2012 High Park Fire west of Fort Collins -- with historic fire effects in the region.

"It's true that the Colorado Front Range has experienced a number of large fires recently," said Schoennagel. "While more area has burned recently compared to prior decades -- with more homes coming into the line of fire -- the severity of recent fires is not unprecedented when we look at fire records going back before the 1900s."

In addition, tree-ring evidence from the new study shows there were several years on the Front Range since the 1650s when there were very large, severe fires. The authors looked at more than 1,200 fire-scarred tree samples and nearly 8,000 samples of tree ages at 232 forest sample sites from Teller County to Larimer County.

The study is one of the largest of its kind ever undertaken in the western United States. The team was especially interested in fire records before about 1920, when effective fire suppression in the West began in earnest.

"In relatively dry ponderosa pine forests of the West, a common assumption is that fires were relatively frequent and of low severity, and not lethal to most large trees, prior to fuel build-up in the 20th century," said Veblen. "But our study results showed that about 70 percent of the forest study area experienced a combination of moderate and high-severity fires in which large percentages of the mature trees were killed."

Along the Front Range, especially at higher elevations, homeowners and fire managers should expect a number of high-severity fires unrelated to any kind of fire suppression and fuel build-up, said Schoennagel. "This matters because high-severity fires are dangerous to people, kill more trees and are trickier and more expensive to suppress."

"Severe fires are not new to most forests in this region," said Sherriff. "What is new is the expanded wildland-urban interface hazard to people and property and the high cost of suppressing fires for society."

In addition, a warming Colorado climate -- 2 degrees Fahrenheit since 1977 -- has become a wild card regarding future Front Range fires, according to the team. While fires are dependent on ignition sources and can be dramatically influenced by high winds, the team expects to see a substantial increase in Front Range fire activity in the low and mid-elevations in the coming years as temperatures continue to warm, a result of rising greenhouses gases in Earth's atmosphere.

Source: University of Colorado at Boulder

New insights into origins of agriculture could help shape future of food

Wheat field (stock image). Agricultural decisions made by our ancestors more than 10,000 years ago could hold the key to food security in the future, according to new research by the University of Sheffield. Credit: © igor / Fotolia

Agricultural decisions made by our ancestors more than 10,000 years ago could hold the key to food security in the future, according to new research by the University of Sheffield.

Scientists, looking at why the first arable farmers chose to domesticate some cereal crops and not others, studied those that originated in the Fertile Crescent, an arc of land in western Asia from the Mediterranean Sea to the Persian Gulf.

They grew wild versions of what are now staple foods like wheat and barley along with other grasses from the region to identify the traits that make some plants suitable for agriculture, including how much edible seed the grasses produced and their architecture.

Dr Catherine Preece, who worked on the study with colleagues from the University's Department of Animal and Plant Sciences and Department of Archaeology, said: "Our results surprised us because numerous other grasses that our ancestors ate, but we do not, can produce just as much seed as wild wheat and barley. It is only when these plants are grown at high densities, similar to what we would find in fields, that the advantage of wild wheat and barley is revealed."

The study identified two key characteristics shared by the wild relatives of current crop plants. Firstly they have bigger seeds, which means they grow into bigger seedlings and are able to get more than their fair share of light and nutrients, and secondly, as adult plants they are less bushy than other grasses and package their big seeds onto fewer stems. This means crop wild relatives perform better than the other wild grasses that they are competing with and are better at growing close together in fields, making them ideal for using in agriculture.

"The results are important because our expanding human population is putting increasing demands on food production," said Dr Preece.

"Before humans learnt how to farm, our ancestors ate a much wider variety of grasses. If we can understand what traits have made some grasses into good crops then we can look for those characteristics in other plants and perhaps identify good candidates for future domestication."

She added: "To shape the future we must understand the past, so the more we can discover about the origins of agriculture, the more information we will have to help us tackle the challenges that face modern day food production."

So far the researchers have been conducting their experiments in greenhouses and their results indicate that the traits affecting how plants compete with each other are crucial factors to determining the success of a crop.

The team now plan to observe how the plants interact in their natural environment by growing them in experimental fields in Turkey, the heart of the Fertile Crescent. They hope that their experiments will yield another crop of important results.

"Cereal breeders are taking an increasing interest in modern crops' wild relatives as a source of useful traits that may help to increase yields or increase resilience to climate change, and our work should help in this process," said Dr Preece.

Dr Preece presented the results of this study to the joint British Ecological Society and the French Ecological Society 11 December 2014 in the Grand Palais, Lille.

Source: University of Sheffield