Walter Gordon: A Pioneer On The Field And Beyond

Walter Gordon was the first African-American student at the Boalt Law School. Courtesy: Cal Athletics

While Walter A. Gordon was a trailblazer during his days as a Cal football player, it’s the ground he broke after he left Berkeley that really made history.

Gordon was a star player along the Bears’ offensive and defensive lines from 1916-18, and after his senior season he became the first All-American football player in Cal history. His selection also made him the second African-American ever to be named All-American.

Gordon went on to become a pioneer in many ways after graduating from Cal. He was the first African-American on the Berkeley police force and the first African-American student at the Boalt Law School, from which he received his JD in 1922. Later in his life, Gordon was appointed to the position of Governor of the Virgin Islands by President Dwight Eisenhower.

Gordon was born in Atlanta, Ga., in 1894 as a second generation free African-American. His father was a Pullman porter, who moved his family to Riverside, Calif., in 1904. Gordon’s father enrolled his children in Riverside Polytechnic High School, a predominantly white high school, in an attempt to give his son a better education. Walter was deeply affected by this and was known to quote his father in later years, asserting that color should not be an influence in access to education.

Walter entered UC Berkeley in 1914 and quickly became involved in a variety of activities. Although now known primarily for football, Gordon was a talented athlete who also excelled in wrestling and boxing, winning the state championship in both of these sports during his time at Cal. He also founded the Alpha Epsilon Chapter of Alpha Phi Alpha, the first African-American Greek-letter fraternity.

In football, Gordon was a star player. He was also the first African-American player on first string. Extremely versatile, he played every position on both the offensive and defensive lines except center throughout his three years on the varsity. He shone as both a blocker and a tackler, a large man who was remembered by all who knew him for both his brute force and a surprising amount of litheness. In 1918, his senior season, Gordon was selected as a member of the third All-American team by the “Father of American Football” himself, Walter Camp. Gordon was the second African-American player to receive the honor of All-American, and the first player from Cal. That same year, Gordon was honored with an outstanding player award, presented in front of a large audience at the Greek Theatre.

Walter Gordon

Gordon experienced a great amount of success during his tenure as an athlete; however, he was also faced with challenges on account of his skin color. During his participation on the Cal heavyweight boxing team, prejudices against African-Americans sometimes kept Gordon out of the ring. In one such incident, the Stanford boxing team refused to compete against Berkeley due to Gordon’s presence. Gordon was forced to sit on the sidelines as another boxer was substituted in his place.

Racism followed Gordon into football as well. Andy Smith (coach of the “Wonder Years” teams) became head coach in 1916 and was unsure of how to navigate the sensitive subject of an African-American player on the team. When Cal was booked to play in Seattle, Smith was uncertain if Gordon should be allowed to come along. When put to a vote, the team decided that if Gordon made first string, he should be able to come with them and play the game. Nevertheless, as soon as the train arrived in Seattle, Gordon left his teammates to find lodging in an African-American part of town, reappearing the next morning to take his place in the game. He was unable at that time to stay in the same hotels as his teammates. Those who knew him say Gordon consciously handled situations regarding race this way, pushing boundaries, while leaving other battles for a later day.

After Gordon’s graduation, Smith hired Gordon as a part-time coach for the football team. He became the head coach for the Goofs, later known as the Ramblers. This team was the equivalent of the junior varsity. Gordon also became the head scout for Smith during the team’s Wonder Years and continued on through the tenure of famed head coach Lynn “Pappy” Waldorf.

Gordon’s responsibilities included both scouting new players and attending the games of Cal’s opponents to study their plays. Those who worked with Gordon claimed he was so perceptive he could predict the other team’s next play based solely off of their movements. Gordon’s skill was also apparent when he assisted in planning plays for Cal. He was thought to have a keen sense of what would happen; one player claimed he felt that when he stepped on the field, he was acting out a scenario that had been written by Gordon. Additionally, he worked closely with quarterbacks. In this era, no plays could be called from the sideline during a game, so the quarterback was essentially an offensive coach on the field. This meant quarterbacks worked a lot with the scouts to determine plays.

Gordon was considered a valuable member of the coaching staff, yet he was an understandably frustrated coach. During the 1920s and 30s, no African-American was allowed to hold any place of significant importance on the staff. Gordon was only allowed to be a coach for the Goofs, though he sometimes ran plays with the varsity linemen. Smith also kept Gordon out of all coaching staff pictures because he felt that seeing an African-American coach would discourage recruits from coming to Cal.

At the beginning of his term, Gordon had to change in a separate room from the rest of the coaches. When he went on scouting trips, he was subject to law allowed by the infamous Plessey v. Ferguson Supreme Court case, which legalized separate transportation and lodging for African-Americans. Gordon was forced to ride on the day coach in trains, regardless of the duration of a trip, and continued to stay in separate accommodations from his white counterparts.

Eventually, Gordon made some headway against the challenges of segregation. He got an “individual privilege” to stay in white hotels while on scouting and coaching jobs in major cities, although he still had to sneak in the side door. The trains also granted concessions, awarding Gordon with his own Pullman section compartment – a much more comfortable way to travel.

Gordon stayed very involved with football at Cal while continuing to expand his horizons. From 1919 to 1929, he served as a member of the Berkeley Police force, where he was once again the first black member. In the ’20s and ’30s, Gordon was active in the NAACP, eventually becoming president of the Alameda County branch. He married May Elisabeth Fisher in 1920, and together they had three children. He attended Boalt Law School and was the first African-American student and JD recipient when he graduated in 1922. Afterwards, he held a joint practice for many years, serving a mostly white client base, while gaining enormous respect in his field. Gordon also served as the vice president of the Lawyer’s Guild of San Francisco and was invited to speak at the L.A. Bar association.

In 1943, Chief Justice Earl Warren, himself a 1914 Boalt graduate, appointed Gordon to the California Adult Authority Board, which dealt with matters of state parole. Gordon ended his private practice a year later and for the next nine years served as chairman of the Board. Throughout his tenure, Gordon was credited for helping to change attitudes towards crime, focusing on humane policies and rehabilitation.

In 1955, President Dwight Eisenhower appointed Gordon to the position of Governor for the Virgin Islands. Gordon served as Governor for three years, during which time he aimed to better the struggling society. After his term, he became a Federal Judge of the District Court of the Virgin Islands, and for the next 10 years used his law degree to try and better people’s lives.

Those who knew him remember Gordon as a charismatic and determined individual. He aimed to be an “inspiration to members of his race” and frequently insisted that the world should not think less of him based on the color of his skin. He took pride in all that he did and what he had accomplished, as well as his history and family.  He made no apologies for his heritage and achieved a great amount in his 82 years before passing away in 1976. He was chosen the California Alumnus of the Year in 1955, received the Citation Award from the Law School in 1964, and was named to the National Football Foundation’s College Hall of Fame in 1975. Today, he is remembered through the Walter Gordon Memorial Fund, established in 1991 to provide money for summer internships at the Law School.

Allison Spivack (UC Berkeley, Class of 2017) did the research and writing of this story as part of her Undergraduate Research Apprenticeship with Professor Margaret Conkey (Anthropology), which has brought together four undergraduates at Berkeley who are researching various aspects of Cal's student-athletes and the athletic program.

Source: Calbears

Screening tools to detect lung, heart disease developed by two high school students

Two Michigan high school students, sisters Ilina and Medha Krishen, have developed screening tools using electronic stethoscopes to detect lung and heart disease. The sisters will present their findings at CHEST 2014 in Austin, Texas next week. Credit: The Krishen family

Two Michigan high school students, sisters Ilina and Medha Krishen, have developed screening tools using electronic stethoscopes to detect lung and heart disease. The sisters will present their findings at CHEST 2014 in Austin, Texas next week.

Ilina Krishen became aware of the dangers of smoking and chemical air pollution when she saw the effects of lung disease on family members. Curious to find a way to detect early lung damage in people exposed to noxious air pollutants, Ilina, a high school senior at Port Huron Northern High School in Michigan, developed a screening mechanism using an electronic stethoscope. An electronic stethoscope overcomes the problem of low sound levels by electronically amplifying body sounds, using an electromagnetic diaphragm that captures the diaphragm movement as an electrical signal.

Ilina recruited 16 smokers, 13 firefighters, and 25 nonsmokers for her test. The electronic stethoscope recorded one breath cycle from each volunteer. Frequency peaks were used to analyze the frequency distribution of breath sounds. Differences of peaks above 125 Hz were analyzed.

Ilina found that the number of peaks was significantly higher in smokers and firefighters, even if the firefighters were nonsmokers. She realized that although firefighters wear protective masks when fighting fires, they often do not wear masks when making a second check of the building after the fire is out. "The firefighters are exposed to many poisonous chemicals that remain in the air after the fire has gone out," said Ilina. "Screening with an electronic stethoscope may be able to detect early changes in lung function in individuals without symptoms of lung disease."

Medha Krishen, Ilina's sister and a junior at Port Huron Northern High School, also presented a study that used an electronic stethoscope to screen student athletes for hypertrophic cardiomyopathy (HCM).

Medha studied 13 individuals: 10 with a normal cardiac sports physical and three with a diagnosis for HCM. Heart sounds were recorded in 5-second periods while the athletes were lying down, standing, and after exercise. Frequency peaks of a frequency amplitude plot were analyzed. Studies showed a significant difference in the distribution of frequency peaks in the two groups between the lying down position and after exercise. Normal athletes showed a lower percentage of peaks above 131 Hz after exercise, while the athletes at risk showed a rise in frequency peaks following exercise.

"When I was in fifth grade, a family friend died after exercise, and I always wanted to learn more about how to prevent something like that happening," said Medha. "My study analyzing heart sound frequencies may be a useful technique that school staff could use to screen for HCM."

The sisters are both athletes -- Ilina is a varsity tennis player, and Medha is an accomplished figure skater -- and they take a personal interest in the health of athletes. They are also nonsmokers and hope to encourage others not to smoke. After Ilina completed her study and showed her study subjects the results of her tests "two or three of the smokers have quit smoking, and that makes me feel good," says Ilina.

Source: American College of Chest Physicians

WHACK! Study measures head blows in girls' lacrosse

Trey Crisco invited lacrosse-playing girls to the lab to measure the impact of their blows as they whacked the head of a laboratory dummy — and to evaluate the performance of protective headgear. Credit: Mike Cohea/Brown University

Lacrosse players swing hard, which is why errant stick blows are the leading cause of concussion in girls' and women's lacrosse. In a new study, researchers measured how much the worst blows accelerate the head and how much different kinds of headgear could reduce those accelerations.

Girls' and women's lacrosse is a different game from the version played by males, said Joseph Crisco, the Henry Frederick Lippitt Professor of Orthopaedic Research in the Alpert Medical School of Brown University and a researcher at Rhode Island Hospital. Females wear far less protective equipment than males do, and injuries -- especially severe head injuries -- are comparatively rare. But recently the debate about whether female players should wear headgear has gained prominence.

Coming to blows

The girls delivered peak performance averaging 60 times the acceleration of Earth's gravity (60g) when they struck the headforms with their lacrosse sticks.

"The goal of our study was to answer the question of what types of head accelerations would you see if you were hit in the head with a stick," said Crisco, who used to coach his daughters in girls lacrosse and also sits on the Sports Science and Safety Committee of US Lacrosse, the national governing body of lacrosse.

To conduct the study, published online in the Journal of Applied Biomechanics, Crisco's team asked seven female lacrosse players aged 12 to 14 to deliver at least 36 whacks each, as hard as they possibly could, to various places on two dummy headforms in the lab.

"The kinds of hits recorded were basically aggressive street fights," Crisco said. "They were really whacking at it, every shaft was broken by the end of the study, which would never happen in a game. The goal was just to give US Lacrosse and the manufacturers some baseline information on the types of accelerations they could expect to see in a worst-case scenario."

They used six different sticks, each outfitted with motion capture markers. The headforms had embedded accelerometers. In a second set of experiments the headforms donned one of four different kinds of protective headgear.

On average across 508 successful blows in the first experiment, the girls swung their sticks about 18 miles an hour, enough to complete two revolutions in less than a second. (One of Crisco's prior studies showed, perhaps not surprisingly, that high school and college players swung their sticks even faster). The peak acceleration the girls delivered to the headforms when they struck them with the shafts of their sticks averaged 60 times the acceleration of Earth's gravity (60g).

That's about three times more force than, say, football players with the kind of celebratory head butt that teammates exchange after a big play, Crisco said.

Headgear dampens blows

The second set of experiments examined what effect headgear might have on the girls' harder whacks (those with speeds around 23 miles an hour). Crisco's team measured the accelerations delivered by 20 whacks from the shaft of each volunteer's stick on both the back and the side of each headform. The headforms wore either nothing, a hard-sided men's lacrosse helmet, a rugby scrum cap, mixed martial arts headgear, or soft headgear designed for girls' and women's field hockey and lacrosse.

The average peak accelerations measured on bare headgear were 81.6g for blows to the side and 150.7g for blows to the back. The men's lacrosse helmet brought the average peak acceleration all the way down to 28.2g on the side and 23.1g on the back. The martial arts and girls lacrosse/field hockey headgear each reduced the accelerations significantly as well, but not nearly as much as the men's helmet. The rugby cap failed to reduce acceleration for blows to the side but dampened blows to the back a little better than the martial arts or lacrosse/field hockey gear.

Headgear, therefore, significantly reduced head accelerations. But Crisco cautioned against a run on headgear at the sporting goods store based on the study.

Generally research has shown that helmets do not protect against concussion -- only against skull fractures and traumatic brain injury. Indeed very little data connects accelerations to concussion risk, and individual susceptibility varies widely. Though some research hints at a figure around 100g, only the hard-sided men's helmet brought accelerations for blows to the back significantly below that figure. And in many game situations, given how little other protective equipment female players wear, Crisco said, a hard-sided helmet could easily cause more injuries that it prevents.

"It could actually make the game more aggressive," Crisco said.

Source: Brown University

Wearable device to track diet under development

A concept of the device with sensor was made through 3-D printing. Credit: The University of Alabama

Sensors and software used to track physical activity are increasingly popular, as smart phones and their apps become more powerful and sophisticated, but, when it comes to food, they all rely on the user to report meals.

Dr. Edward Sazonov, an associate professor of electrical and computer engineering at The University of Alabama, hopes to change that through development of a sensor worn around the ear that would automatically track diet, giving medical professionals and consumers accurate information that can be missed with self-reporting.

"Weight gain comes from an unbalance of the energy we take in versus the energy we expend," Sazonov said. "We can estimate diet and nutrient intake, but the primary method is self-reporting. The sensor could provide objective data, helping us better understand patterns of food intake associated with obesity and eating disorders."

Sazonov is the lead on a $1.8 million, five-year grant from the National Institute of Health to test the practical accuracy of the wearable sensor in tracking diet. Already proven viable, the device will be updated, further miniaturized and validated in a more formal, robust experiment in the community.

Called an Automatic Ingestion Monitor, or AIM, it has potential to monitor eating by automatically detecting and capturing imagery of food intake and to estimate the mass and the energy content of ingested food.

The sensor feels vibrations from movement in the jaw during food intake, and the device is programmed to filter out jaw motions, such as talking, that are not coming from drinking or eating. Estimates of energy intake would be taken from the pictures of food or drink.

More than two-thirds of adults in the United States are clinically overweight or obese, according to estimates from the Center for Disease Control and Prevention.

"Eating may be an unconscious, even automatic behavior for some individuals, and the literature is full of examples of dietary behaviors which increase the risk for overeating," Sazonov said.

In a study, the AIM will be tested against the accuracy of an alternative method, the use of a doubly-labeled water to track energy use by humans. That method measures the body's elimination rate of stable isotopes of hydrogen and oxygen added to the water, a process that can take two weeks. The information can be used to estimate how many calories a person consumes over a period of time.

However, this method is expensive and requires medical specialization, and, unlike the proposed AIM, does not track eating behavior.

The information provided by AIM could be used to improve behavioral weight loss strategies or to develop new kinds of weight-loss interventions. In addition, the AIM could also provide an objective method of assessing the effectiveness of pharmacological and behavioral interventions for eating disorders.

It's likely the technology's first application would be as a medical device, but Sazonov said it's possible it could become a consumer device that would eliminate the need for health-conscious people to keep a record of their diet.

Source: University of Alabama

Football players found to have brain damage from mild 'unreported' concussions

The images from the Ben-Gurion University of the Negev JAMA Neurology study represent Blood-Brain Barrier (BBB) Permeability in Football Players (A) vs. a control group (B). The players in the pathological-BBB group (B) presented focal BBB lesions in different cortical regions including the temporal (player 4), frontal (player 5), and parietal (player 6) lobes. Both gray and white matter were involved. Credit: Image courtesy of American Associates, Ben-Gurion University of the Negev

A new, enhanced MRI diagnostic approach was, for the first time, able to identify significant damage to the blood-brain barrier (BBB) of professional football players following "unreported" trauma or mild concussions. Published in the current issue of JAMA Neurology, this study could improve decision making on when an athlete should "return to play."

According to Prof. Alon Friedman, from the Ben-Gurion University Brain Imaging Research Center and discoverer of the new diagnostic, "until now, there wasn't a diagnostic capability to identify mild brain injury early after the trauma. In the NFL, other professional sports and especially school sports, concern has grown about the long-term neuropsychiatric consequences of repeated mild Traumatic Brain Injury (mTBI) and specifically sports-related concussive and sub-concussive head impacts."

The paper, published by researchers at Ben-Gurion University of the Negev (BGU) and Soroka University Medical Center, describes a new diagnostic approach using Magnetic Resonance Imaging (MRI) for detection and localization of vascular pathology and blood-brain barrier breakdown in football players.

The images from the Ben-Gurion University of the Negev JAMA Neurology study represent Blood-Brain Barrier (BBB) Permeability in Football Players (A) vs. a control group (B). The players in the pathological-BBB group (B) presented focal BBB lesions in different cortical regions including the temporal (player 4), frontal (player 5), and parietal (player 6) lobes. Both gray and white matter were involved.

"The goal of our study was to use our new method to visualize the extent and location of BBB dysfunction in football players using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) on a Phillips 3-T Ingenia. Specifically, it generates more detailed brain maps showing brain regions with abnormal vasculature, or a 'leaky BBB.' "

Study participants included 16 football players from Israel's professional football team, Black Swarm, as well as 13 track and field athletes from Ben-Gurion University who served as controls. All underwent the newly developed MRI-based diagnostic.

The DCE-MRIs were given between games during the season and revealed significant damage.

Forty percent of the examined football players with unreported concussions had evidence of "leaky BBB" compared to 8.3 percent of the control athletes.

"The group of 29 volunteers was clearly differentiated into an intact-BBB group and a pathological-BBB group," Friedman explains. "This showed a clear association between football and increased risk for BBB pathology that we couldn't see before. In addition, high-BBB permeability was found in six players and in only one athlete from the control group."

Friedman also explains that not all the players showed pathology. This indicates that repeated, mild concussive events might impact some players differently than others. This level of diagnosis of individual players can provide the basis of more rational decision making on "return to play" for professionals as well amateurs of any age.

"Generally, players return to the game long before the brain's physical healing is complete, which could exacerbate the possibility of brain damage later in life," says Friedman.

A decade of research in the BGU Laboratory for Experimental Neurosurgery has shown that vascular pathology, and specifically dysfunction of the blood-brain barrier (BBB), plays a key role in brain dysfunction and degeneration, and may be an underlying cause of neurodegenerative complications after brain injuries.

The BBB is a highly selective permeable membrane that separates circulating blood from extracellular fluid. It protects the brain by preventing many dangerous substances from penetrating, and therefore is not meant to be damaged.

Medical researchers, including Friedman's group at BGU, are working to find ways to find drugs that will target the BBB and facilitate its repair, allowing for the prevention of Alzheimer's disease and other brain-related disease.

"Prof. Friedman has been able to conduct this breakthrough brain research using the state-of-the-art MRI machine donated as a result of contributions from American Associates, Ben-Gurion University of the Negev (AABGU)," explains Doron Krakow, AABGU executive vice president. "We believe that with continued support, Prof. Friedman and the DCE-MRI can help render more accurate and informed decisions by athletes and others exposed to mild concussions about when to resume activities."

Source: American Associates, Ben-Gurion University of the Negev

Tailored 'activity coaching' by smartphone

Tailored activity monitoring. Credit: Image courtesy of University of Twente

Today's smartphone user can obtain a lot of data about his or her health, thanks to built-in or separate sensors. Researcher Harm op den Akker of the University of Twente (CTIT Institute) now takes this health monitoring to a higher level. Using the system he developed, the smartphone also acts as an 'activity coach': it advices the user to walk or take a rest. In what way the user wants to be addressed, is typically something the system learns by itself. Op den Akker conducted his research at Roessingh Research and Development in Enschede. October 17, he defends his PhD-thesis.

The new telemedicine system was tested for three months, among a group of COPD patients -- a chronic lung disease. For these patients, physical activity is very important but it can also lead to an oppressed feeling and thus, to over-cautiousness. Using the coaching system of Van den Akker, the patients carry a small movement sensor and a smartphone. The system calculates if it is advisable to take a rest or, on the other hand, have a walk. The system is 'context aware': it looks at the time of day, the weather, the surroundings of the patient and determines if the time is right for taking some exercise.

Tone of voice

In addition, the system knows how the patient wants to be addressed. Some people don't mind an imperative tone of voice 'go for a 10 minutes' walk', others prefer a more friendly advice: 'what if you would take a walk in the park?' Op den Akker designed learning algorithms for this: the system learns the preferences of the user by itself. Future versions of the system may not use text messages anymore, but an 'avatar' on the screen, enabling interaction with the user as well. For this, Op den Akker has started starting cooperation with the Human Media Interaction group of the University of Twente.

Roessingh Research & Development (RRD) is the research department of Roessingh rehabilitation centre in Enschede, The Netherlands. RRD closely cooperates with the University of Twente in many projects. Op den Akker conducted his research at RRD and UT's CTIT Institute, under supervision of Hermie Hermens, Professor in Neuromuscular Control and Telemedicine. A spin-off company of the university, Inertia Technology, developed the movement sensor used in this project.

Op den Akker's PhD-thesis is titled 'Smart tailoring of real-time physical activity coaching systems'.

Source: University of Twente

Charged graphene gives DNA a stage to perform molecular gymnastics

DNA interacts with charged graphene and contorts into sequence-specific shapes when the charge is changed. Credit: Photo courtesy Alek Aksimentiev

When Illinois researchers set out to investigate a method to control how DNA moves through a tiny sequencing device, they did not know they were about to witness a display of molecular gymnastics.

Fast, accurate and affordable DNA sequencing is the first step toward personalized medicine. Threading a DNA molecule through a tiny hole, called a nanopore, in a sheet of graphene allows researchers to read the DNA sequence; however, they have limited control over how fast the DNA moves through the pore. In a new study published in the journal Nature Communications, University of Illinois physics professor Aleksei Aksimentiev and graduate student Manish Shankla applied an electric charge to the graphene sheet, hoping that the DNA would react to the charge in a way that would let them control its movement down to each individual link, or nucleotide, in the DNA chain.

"Ideally, you would want to step the DNA through the nanopore one nucleotide at a time," said Aksimentiev. "Take a measurement and then have another nucleotide in the sensing hole. That's the goal, and it hasn't been realized yet. We show that, to some degree, we can control the process by charging the graphene."

The researchers found that a positive charge in the graphene speeds up DNA movement through the nanopore, while a negative charge stops the DNA in its tracks. However, as they watched, the DNA seemed to dance across the graphene surface, pirouetting into shapes they had never seen, specific to the sequence of the DNA nucleotides.

"It reminds me of Swan Lake," Aksimentiev said. "It's very acrobatic. We were very surprised by the variety of DNA conformations that we can observe at the surface of graphene when we charge it. There is one sequence that starts out laying down on the surface, and when we change the charge, they all tilt on the side like they are doing a one-armed push-up. Then we also have nucleotides that would lay back, or go up like a ballerina en pointe."

Aksimentiev hypothesizes that the conformations are so different and so specific to the sequence because each nucleotide has a slightly different distribution of electrons, the negatively charged parts of the atoms. There is even a visible difference when a nucleotide is methylated, a tiny chemical change that can turn a gene on or off.

By switching the charge in the graphene, the researchers can control not only the DNA's motion through the pore, but also the shape the DNA contorts into.

"Because it's reversible, we can force it to adopt one conformation and then force it to go back. That's why we call it gymnastics," Aksimentiev said.

The researchers extensively used the Blue Waters supercomputer at the National Center for Supercomputing Applications, housed at the University of Illinois. They mapped each individual atom in the complex DNA molecule and ran numerous simulations of many different DNA sequences. Supercomputing power was essential to carrying out the work, Aksimentiev said.

"This is a really computationally intensive project," he said. "Having access to Blue Waters was essential because with the sheer number of simulations, we would not have been able to finish them. It would have taken too long."

The next step is to combine a charged nanopore setup with a sensor to build a DNA sequencing device that would incorporate both motion control and nucleotide recognition. The researchers also hope to explore the unexpected conformational changes for insights into epigenetics, the field that studies how genes are expressed and moderated.

"DNA is much more complicated than just a double helix. It's a complex molecule that has many properties, and we are still uncovering them," Aksimentiev said.

Video animation of DNA dancing as the graphene charge changes:


Source: University of Illinois at Urbana-Champaign